Phenotypes Associated with This Genotype

Genotype
MGI:5014832

• Allelic Composition: Trp53^tm1.2Awbr/Trp53^tm1.2Awbr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:173271 )

• median survival is 111 days compared with 149 days for null homozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:173271 )

• in the colon of some mice

neoplasm

increased tumor incidence ( J:173271 )

increased intestinal adenoma incidence ( J:173271 )

• in the colon of some mice

increased ovary tumor incidence ( J:173271 )

♀ • luteoma of pregnancy in some mice

increased T cell derived lymphoma incidence ( J:173271 )

• in 10% of mice

increased lung adenoma incidence ( J:173271 )

• in some mice

increased hibernoma incidence ( J:173271 )

• in the skin and colon of some mice

increased B cell derived lymphoma incidence ( J:173271 )

• diffuse large B cell lymphoma (DLBCL) B220+ in 32% of mice and B220- in 15% of mice

• 7% of mice exhibit DLBCL and sarcoma

increased histiocytic sarcoma incidence ( J:173271 )

• all mice exhibit malignant fibrous histiocytomas with angiogenesis

increased osteosarcoma incidence ( J:173271 )

• in 17% of mice

• 7 of 9 mice exhibit metastasized osteosarcomas

reproductive system

increased ovary tumor incidence ( J:173271 )

♀ • luteoma of pregnancy in some mice

skeleton

increased osteosarcoma incidence ( J:173271 )

• in 17% of mice

• 7 of 9 mice exhibit metastasized osteosarcomas

immune system

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased splenocyte proliferation ( J:173271 )

• in the red pulp

enlarged spleen ( J:173271 )

abnormal lymphocyte morphology ( J:173271 )

• prior to and after tumor development, mice exhibit lymphocyte aggregates in the liver and lungs unlike wild-type mice

increased circulating interferon-gamma level ( J:173271 )

increased circulating interleukin-3 level ( J:173271 )

increased circulating interleukin-5 level ( J:173271 )

increased circulating interleukin-6 level ( J:173271 )

increased circulating tumor necrosis factor level ( J:173271 )

abnormal Peyer's patch morphology ( J:173271 )

• prominent in the colon prior to and after tumor development

increased inflammatory response ( J:173271 )

• generalized inflammation in the liver, lung, and adipose tissue 30% of mice develop inflammation

adipose tissue inflammation ( J:173271 )

• adipose tissue exhibits increased inflammatory response compared with wild-type mice

liver inflammation ( J:173271 )

• lobulitis, hepatitis, or cirrhosis of the liver in 11% of mice

lung inflammation ( J:173271 )

cellular

abnormal cell cycle ( J:173271 )

• irradiated cells fail to exhibit cell cycle arrest unlike similarly treated wild-type cells

• more untreated and irradiated cells are in S phase compared with wild-type cells

decreased cellular sensitivity to gamma-irradiation ( J:173271 )

• irradiated cells fail to exhibit cell cycle arrest or increased apoptosis unlike similarly treated wild-type cells

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased cell proliferation ( J:173271 )

• in the bone marrow, splenic red pulp, thymic medulla, and the skin

increased splenocyte proliferation ( J:173271 )

• in the red pulp

integument

abnormal coat/ hair morphology ( J:173271 )

• fur development is delayed

homeostasis/metabolism

increased circulating interferon-gamma level ( J:173271 )

increased circulating interleukin-3 level ( J:173271 )

increased circulating interleukin-5 level ( J:173271 )

increased circulating interleukin-6 level ( J:173271 )

increased circulating tumor necrosis factor level ( J:173271 )

liver/biliary system

liver inflammation ( J:173271 )

• lobulitis, hepatitis, or cirrhosis of the liver in 11% of mice

hepatic steatosis ( J:173271 )

• prior to and after tumor development

liver cirrhosis ( J:173271 )

• lobulitis, hepatitis, or cirrhosis of the liver in 11% of mice

nervous system

increased brain size ( J:173271 )

exencephaly ( J:173271 )

• in female mice

absent optic nerve ( J:173271 )

respiratory system

lung inflammation ( J:173271 )

increased lung adenoma incidence ( J:173271 )

• in some mice

vision/eye

absent optic nerve ( J:173271 )

adipose tissue

adipose tissue inflammation ( J:173271 )

• adipose tissue exhibits increased inflammatory response compared with wild-type mice

cardiovascular system

vascular inflammation ( J:173271 )

• 11% of mice exhibit vasculitis affecting the skin, heart, aorta, kidney, or seminal vesicles vessels unlike wild-type mice

hematopoietic system

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased splenocyte proliferation ( J:173271 )

• in the red pulp

enlarged spleen ( J:173271 )

abnormal common myeloid progenitor cell morphology ( J:173271 )

• bone marrow cells produce more granulocyte and macrophage colony forming units compared with wild-type cells

extramedullary hematopoiesis ( J:173271 )

• prior to and after tumor development

abnormal lymphocyte morphology ( J:173271 )

• prior to and after tumor development, mice exhibit lymphocyte aggregates in the liver and lungs unlike wild-type mice

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased ovary tumor incidence ( J:173271 )

♀ • luteoma of pregnancy in some mice

increased T cell derived lymphoma incidence ( J:173271 )

• in 10% of mice

growth/size/body

enlarged spleen ( J:173271 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diffuse large B-cell lymphoma		DOID:0050745		J:173271