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Targeted Allele Detail
Symbol: Cdh1tm2Kem
Name: cadherin 1; targeted mutation 2, Rolf Kemler
MGI ID: MGI:2389020
Synonyms: Ecadfl, E-cadherinflox, E-cadherinfloxed, E-cadlox
Gene: Cdh1  Location: Chr8:107329983-107396878 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Alliance: Cdh1tm2Kem page
Germline Transmission:  Earliest citation of germline transmission: J:77170
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSingle loxP sites flanked a region encompassing exons 6 through 10 followed by a floxed selection cassette was excised via in vitro cre mediated recombination. (J:77170)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Cdh1tm2Kem
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  165 strains or lines available
Original:  J:77170 Boussadia O, et al., E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002 Jul;115(1-2):53-62
All:  72 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory