Symbol
Name
ID

Trp53
transformation related protein 53
MGI:98834

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Abnormal femoral metaphysis morphology

Abnormal tibial metaphysis morphology

Abnormal metaphysis morphology

Joint swelling

Bone pain

Pathologic fracture

Vertebral compression fracture

Back pain

Osteopenia

Osteoporosis

Osteolysis

Gout

Osteosarcoma

Disease(s) Associated with TP53

choroid plexus papilloma

coronary artery disease

Li-Fraumeni syndrome

Li-Fraumeni syndrome 1

multiple myeloma

osteosarcoma

pancreatic cancer

Mouse Phenotypes

short mandible

decreased bone mineral density of humerus

short humerus

abnormal tibia morphology

increased osteosarcoma incidence

abnormal spine curvature

lordokyphosis

decreased bone mineral density of femur

decreased bone mineral density

osteoporosis

osteopetrosis

abnormal skeleton development

Availability

Mouse Genotype

Trp53^tm1.1Manf/Trp53^tm1.1Manf

Trp53^tm1.2Awbr/Trp53^tm1.2Awbr

Trp53^tm1Brd/Trp53^tm1Brd

Trp53^tm1Tyj/Trp53^tm1Tyj

Trp53^Bbl/Trp53⁺

Trp53^bhy/Trp53⁺

Trp53^tm1.2Awbr/Trp53⁺

Trp53^tm1Brd/Trp53⁺

Trp53^tm1Brd/Trp53^tm8Xu

Trp53^tm1Glo/Trp53⁺

Trp53^tm1Ldo/Trp53⁺

Trp53^tm1Tyj/Trp53⁺

Trp53^tm2.1Tyj/Trp53⁺

Trp53^tm3.1Glo/Trp53⁺

Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Tg(tetO-RNAi:Trp53)ASlowe/0

Tg(Trp53A135V)L3Ber/0

Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Trp53^tm1Brn/Trp53^tm1Brn (conditional)

Trp53^tm1Brn/Trp53⁺
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Tg(CMV-cre)1Cgn/0
Trp53^tm4Att/Trp53⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23