Phenotypes Associated with This Genotype

Genotype
MGI:3799369

• Allelic Composition: Tg(Trp53R172H)8512Jmr/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

cellular

chromosomal instability ( J:46426 )

• tumor cells exhibit an increase in genomic instability (tetraploid and aneuploid) compared to tumor cells in wild-type mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:46426 )

N • mammary gland development is normal

increased mammary adenocarcinoma incidence ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:46426