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Trp53tm3Tyj
Targeted Allele Detail
Summary
Symbol: Trp53tm3Tyj
Name: transformation related protein 53; targeted mutation 3, Tyler Jacks
MGI ID: MGI:3039265
Synonyms: LSL-p53R270H, p53LSL•R270H, p53LSL-R270H, p53 LSL-R270H
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm3Tyj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95316
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting construct was designed to insert a loxP site flanked STOP cassette into intron 1 and a p.R270H missense mutation into exon 8. (J:126915)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm3Tyj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
References
Original:  J:95316 Olive KP, et al., Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory