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Phenotypes Associated with This Genotype
Genotype
MGI:5298084
Allelic
Composition
Krastm4Tyj/Kras+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• lesions are squamous cell carcinomas (SCCs)characterized by fibroblast-like shaped cells and disruption of basal lamina
• numerous microscopic and small invasive SCCs are observed in the dermis of the back skin in addition to the macroscopic lesions

integument
• within 2 months of tamoxifen treatment, animals develop rapidly growing ulcerative skin lesions in the back skin
• lesions are squamous cell carcinomas (SCCs)characterized by fibroblast-like shaped cells and disruption of basal lamina
• numerous microscopic and small invasive SCCs are observed in the dermis of the back skin in addition to the macroscopic lesions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
squamous cell carcinoma DOID:1749 J:172048


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory