About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3584471
Allelic
Composition
Trp53tm1Tyj/Trp53tm3.1Tyj
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Trp53tm3.1Tyj mutation (2 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean life span is 4.6 months
• a slight decrease is seen in the number of females born

neoplasm
• 43% have multiple tumors
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (55% compared to 66%)
• carcinomas are seen in 18% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas
• most carcinomas are derived from epithelial cells

endocrine/exocrine glands
• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53tm1Tyj homozygotes (55% compared to 66%)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Li-Fraumeni syndrome DOID:3012 OMIM:PS151623
J:95316


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory