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Symbol
Name
ID
Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to neoplasm
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Leukemia
Acute leukemia
Acute lymphoblastic leukemia
Acute myeloid leukemia
Lymphoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
T-cell lymphoma
Multiple myeloma
Myelodysplasia
Neoplasia of the nasopharynx
Choriocarcinoma
Breast carcinoma
Neoplasm of the rectum
Colorectal polyposis
Adenocarcinoma of the colon
Hereditary nonpolyposis colorectal carcinoma
Adenomatous colonic polyposis
Colon cancer
Neoplasm of the stomach
Stomach cancer
Neoplasm of the liver
Hepatocellular carcinoma
Neoplasm of the pancreas
Pancreatic adenocarcinoma
Neoplasm of the gastrointestinal tract
Adenocarcinoma of the small intestine
Adrenocortical carcinoma
Thyroid carcinoma
Non-medullary thyroid carcinoma
Papillary thyroid carcinoma
Retinoblastoma
Testicular neoplasm
Prostate neoplasm
Prostate cancer
Ovarian neoplasm
Ovarian carcinoma
Uterine leiomyosarcoma
Renal neoplasm
Nephroblastoma
Renal cell carcinoma
Transitional cell carcinoma of the bladder
Basal cell carcinoma
Plexiform neurofibroma
Choroid plexus papilloma
Rhabdomyosarcoma
Osteosarcoma
Astrocytoma
Pleomorphic xanthoastrocytoma
Ependymoma
Glioblastoma multiforme
Oligodendroglioma
Choroid plexus carcinoma
Neoplasm of the central nervous system
Medulloblastoma
Neuroblastoma
Neoplasm of the lung
Lung adenocarcinoma
Neoplasm of the larynx
Neoplasm
Neoplasm of head and neck
Melanoma
Central primitive neuroectodermal tumor
Soft tissue sarcoma
Disease(s) Associated with TP53
acute myeloid leukemia
breast cancer
choroid plexus papilloma
colorectal cancer
hepatocellular carcinoma
Li-Fraumeni syndrome
Li-Fraumeni syndrome 1
mismatch repair cancer syndrome
multiple myeloma
myelodysplastic syndrome
nasopharynx carcinoma
osteosarcoma
pancreatic cancer
prostate cancer
stomach cancer
thyroid gland papillary carcinoma

Mouse Phenotypes
neoplasm
increased intestinal adenoma incidence
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
increased ovary tumor incidence
increased pancreas tumor incidence
increased testis tumor incidence
increased testicular teratoma incidence
increased T cell derived lymphoma incidence
decreased incidence of tumors by chemical induction
increased incidence of tumors by chemical induction
increased skin tumor incidence
increased pilomatricoma incidence
increased skin papilloma incidence
increased skin squamous cell carcinoma incidence
increased liver tumor incidence
increased hepatocellular carcinoma incidence
increased leiomyosarcoma incidence
increased rhabdomyosarcoma incidence
abnormal tumor pathology
increased metastatic potential
abnormal tumor morphology
decreased tumor growth/size
tumor regression
abnormal tumor incidence
increased lung adenoma incidence
increased adenoma incidence
increased hamartoma incidence
increased hemangioma incidence
increased leukemia incidence
increased lipoma incidence
increased hibernoma incidence
increased lymphoma incidence
increased B cell derived lymphoma incidence
increased splenic marginal zone lymphoma incidence
increased histiocytic sarcoma incidence
increased medulloblastoma incidence
increased carcinoma incidence
increased adenocarcinoma incidence
increased lung adenocarcinoma incidence
increased endometrial carcinoma incidence
increased spindle cell carcinoma incidence
increased squamous cell carcinoma incidence
increased teratocarcinoma incidence
increased sarcoma incidence
increased fibrosarcoma incidence
increased hemangiosarcoma incidence
increased osteosarcoma incidence
increased myoepithelioma incidence
increased teratoma incidence
increased incidence of tumors by ionizing radiation induction
increased brain tumor incidence
increased glioma incidence
increased astrocytoma incidence
increased reproductive system tumor incidence
increased lung tumor incidence
increased urinary system tumor incidence
decreased tumor incidence
increased tumor incidence
abnormal tumor latency
decreased tumor latency
increased tumor latency
Availability Mouse Genotype
Trp53Bbl/Trp53Bbl
Trp53bhy/Trp53bhy
Trp53tm1.1Brn/Trp53tm1.1Brn
Trp53tm1.1Dgj/Trp53tm1.1Dgj *
Trp53tm1.1Hwan/Trp53tm1.1Hwan
Trp53tm1.1Thst/Trp53tm1.1Thst
Trp53tm1.1Umol/Trp53tm1.1Umol
Trp53tm1.1Wgu/Trp53tm1.1Wgu *
Trp53tm1.1Xlu/Trp53tm1.1Xlu *
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1Adv/Trp53tm1Adv
Trp53tm1Brd/Trp53tm1Brd
Trp53tm1Gev/Trp53tm1Gev
Trp53tm1Glo/Trp53tm1Glo
Trp53tm1Holl/Trp53tm1Holl *
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Thst/Trp53tm1Thst
Trp53tm1Tyj/Trp53tm1Tyj *
Trp53tm1Wahl/Trp53tm1Wahl
Trp53tm1Xu/Trp53tm1Xu *
Trp53tm1Yjc/Trp53tm1Yjc
Trp53tm2.1Kasa/Trp53tm2.1Kasa *
Trp53tm2.1Thst/Trp53tm2.1Thst
Trp53tm2.1Umol/Trp53tm2.1Umol
Trp53tm2.1Wgu/Trp53tm2.1Wgu *
Trp53tm2Glo/Trp53tm2Glo
Trp53tm2Mok/Trp53tm2Mok
Trp53tm2Xu/Trp53tm2Xu
Trp53tm3.1Glo/Trp53tm3.1Glo
Trp53tm3Wahl/Trp53tm3Wahl
Trp53tm4.1Glo/Trp53tm4.1Glo *
Trp53tm4Glo/Trp53tm4Glo
Trp53tm4Tyj/Trp53tm4Tyj
Trp53tm4Xu/Trp53tm4Xu
Trp53tm7.1Xu/Trp53tm7.1Xu
Trp53Bbl/Trp53+
Trp53bhy/Trp53+
Trp53tm1.1Hwan/Trp53+
Trp53tm1.1Rfo/Trp53+ *
Trp53tm1.1Thst/Trp53+
Trp53tm1.2Awbr/Trp53+
Trp53tm1Adv/Trp53+
Trp53tm1Brd/Trp53+
Trp53tm1Brd/Trp53tm1Ldo
Trp53tm1Glo/Trp53+
Trp53tm1Glo/Trp53tm4Glo
Trp53tm1Holl/Trp53tm7.1Xu
Trp53tm1Ldo/Trp53+
Trp53tm1Thst/Trp53+
Trp53tm1Thst/Trp53tm1.1Thst
Trp53tm1Tyj/Trp53+ *
Trp53tm1Tyj/Trp53tm1.1Umol
Trp53tm1Tyj/Trp53tm2.1Tyj
Trp53tm1Tyj/Trp53tm2.1Umol
Trp53tm1Tyj/Trp53tm3.1Tyj
Trp53tm2.1Tyj/Trp53+
Trp53tm2Thst/Trp53tm2.1Thst
Trp53tm3.1Glo/Trp53+
Trp53tm3.1Glo/Trp53tm4Glo
Trp53tm3.1Tyj/Trp53+
Trp53tm4Xu/Trp53+ *
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Tg(tetO-RNAi:Trp53)ASlowe/0
Trp53tm1.1Brn/Trp53tm1.1Brn
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm1Brd/Trp53tm1Brd
Tg(Nes-cre)1Kln/0  (conditional)
Trp53tm1Brd/Trp53tm1Brd
Tg(Lck-cre)1Cwi/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn  (conditional) *
Trp53tm1Brn/Trp53tm1Brn
Tg(GFAP-cre)25Mes/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)105Ayn/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(Upk2-cre)1Rkl/0  (conditional)
*
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Trp53tm1Brn/Trp53tm1Brn  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(Cdh16-cre)91Igr/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT5-cre/PGR)1Der/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Tfln/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(Nes-cre/ERT2,-ALPP)1Sbk/0  (conditional)
Tg(Tek-cre)1Ywa/0
Trp53tm1Brn/Trp53tm1Brn  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(Wap-cre)51Nki/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(MMTV-cre)AElee/0  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(MMTV-cre)BElee/0  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(Wap-rtTA-cre)10Whl/0  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(GFAP-cre)25Mes/0  (conditional)
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0  (conditional)
*
Cd19tm1(cre)Cgn/Cd19+
Trp53tm1Yjc/Trp53tm1Yjc  (conditional)
*
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Trp53tm5Tyj/Trp53tm5Tyj  (conditional)
Trp53tm6Xu/Trp53tm6Xu
Tg(Lck-cre)1Cwi/0  (conditional)
Amhr2tm3(cre)Bhr/Amhr2+
Trp53tm2Tyj/Trp53+  (conditional)
*
Trp53tm1Brn/Trp53+
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+  (conditional)
Trp53tm1.1Brn/Trp53+
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm1.1Brn/Trp53tm3Tyj
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Tfln/0  (conditional)
Trp53tm1Brn/Trp53+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)
Trp53tm1Brn/Trp53tm1.1Brn  (conditional)
Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0  (conditional)
Trp53tm1Elee/Trp53+
Tg(MMTV-cre)AElee/0  (conditional)
Trp53tm1Elee/Trp53tm1Tyj
Tg(GFAP-cre)25Mes/0  (conditional)
Trp53tm1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Trp53tm3.1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Trp53tm3Tyj/Trp53+
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm3Tyj/Trp53+
Tg(Wap-cre)11738Mam/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory