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Symbol
Name
ID 		Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to growth/size/body
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Splenomegaly
Hepatosplenomegaly
Abnormal abdomen morphology
Peritoneal abscess
Tall stature
Weight loss
Obesity
Disease(s) Associated with TP53
coronary artery disease
Graves' disease
multiple myeloma
osteosarcoma
pancreatic cancer

Mouse Phenotypes
increased heart weight
enlarged heart
cardiac hypertrophy
square face
cleft upper lip
oral leukoplakia
cleft palate
abnormal tongue morphology
protruding tongue
abnormal outer ear morphology
increased ear pigmentation
ovary cyst
growth/size/body region phenotype
decreased body weight
weight loss
decreased body size
postnatal growth retardation
enlarged liver
hepatosplenomegaly
liver hyperplasia
enlarged spleen
increased spleen weight
spleen hyperplasia
Availability Mouse Genotype
Trp53tm1.1Manf/Trp53tm1.1Manf
Trp53tm1.1Thst/Trp53tm1.1Thst
Trp53tm1.1Tldo/Trp53tm1.1Tldo
Trp53tm1.1Xlu/Trp53tm1.1Xlu
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Tyj/Trp53tm1Tyj
Trp53tm1Yjc/Trp53tm1Yjc
Trp53tm2Wahl/Trp53tm2Wahl
Trp53tm1.1Thst/Trp53+
Trp53tm1.1Tldo/Trp53+ *
Trp53tm1Brd/Trp53tm8Xu
Trp53tm1Ldo/Trp53+
Trp53tm1Thst/Trp53+
Trp53tm1Thst/Trp53tm1.1Thst
Trp53tm3.1Glo/Trp53+
Tg(Trp53A135V)L3Ber/0
Trp53tm1Brn/Trp53tm1Brn  (conditional)
Trp53tm1Att/Trp53+
Tg(KRT5-cre)5132Jlj/0  (conditional)
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory