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Gene Expression Data
Assay Details
Assay
Reference: J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8350556
Gene symbol: Slc16a3
Gene name: solute carrier family 16 (monocarboxylic acid transporters), member 3
Antibody: anti-Mct4 (AB3314P)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen E8.75 - 3F/G; Ext1E: embryonic day 8.75 (more )
Note: Littermate control. Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS13: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 1E MCT4 E8.75 , Extended Data 1E Merge E8.75 , 3G E8.75 , 3F E8.75 Expression is seen in mature SynTII cells.
Specimen E9.0 - Ext1E: embryonic day 9.0 (more )
Note: Littermate control. Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS14: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 1E MCT4 E9.0 , Extended Data 1E Merge E9.0 Expression is seen in mature SynTII cells.
Specimen E9.25 - 3F/G; 6C Chp1 +/-; Ext1E; Ext8C: embryonic day 9.25; Chp1em1(IMPC)Tcp/Chp1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS14: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6C Chp1+/- MCT4 , 6C Chp1+/- Merge , Extended Data 8C +/- MCT4 , 3F E9.25 , 3G E9.25 , Extended Data 1E Merge E9.25 , Extended Data 8C +/- Merge , Extended Data 1E MCT4 E9.25 Expression is seen in mature SynTII cells.
Specimen E9.5 - Ext1E: embryonic day 9.5 (more )
Note: Littermate control. Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 1E MCT4 E9.5 , Extended Data 1E Merge E9.5 Expression is seen in mature SynTII cells.
Specimen E9.75 - 3F/G; 6B Got2 +/-; Ext1E; Ext14C: embryonic day 9.75; Got2em1(IMPC)Mbp/Got2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6B Got+/- Merge , 3F E9.75 , Extended Data 1E Merge E9.75 , Extended Data 14C +/- Merge , Extended Data 1E MCT4 E9.75 , 6B Got+/- MCT4 , Extended Data 14C +/- MCT4 , 3G E9.75 Expression is seen in mature SynTII cells.
Specimen E10.0 - Ext1E: embryonic day 10.0 (more )
Note: Littermate control. Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS16: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 1E Merge E10.0 , Extended Data 1E MCT4 E10.0 Expression is seen in mature SynTII cells.
Specimen E10.5 - 3F/G; 6F Traf7 +/-; Ext1E; Ext19F: embryonic day 10.5; Traf7em1(IMPC)Tcp/Traf7+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 1E Merge E10.5 , 6F Traf7+/- Merge , Extended Data 1E MCT4 E10.5 , Extended Data 19F +/- MCT4 , 6F Traf7+/- MCT4 , 3G E10.5 , Extended Data 19F +/- Merge , 3F E10.5 Expression is seen in mature SynTII cells.
Specimen 6A Gmeb2 +/-; Ext11C: embryonic day 9.5; Gmeb2em1(IMPC)J/Gmeb2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6A Gmemb2+/- MCT4 , 6A Gmemb2+/- Merge , Extended Data 11C +/- MCT4 , Extended Data 11C +/- Merge Expression is seen in mature SynTII cells.
Specimen 6A Gmeb2 -/-; Ext11C: embryonic day 9.5; Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 11C -/- MCT4 , 6A Gmemb2-/- MCT4 , Extended Data 11C -/- Merge , 6A Gmemb2-/- Merge Expression is seen in mature SynTII cells; in the mutant a mild chorioallantoic branching defect was observed.
Specimen 6B Got2 -/-: embryonic day 9.5; Got2em1(IMPC)Mbp/Got2em1(IMPC)Mbp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6B Got-/- MCT4 , Extended Data 14C -/- Merge , Extended Data 14C -/- MCT4 , 6B Got-/- Merge Expression is seen in mature SynTII cells; in the mutant a severe chorioallantoic branching defect was observed.
Specimen 6C Chp1 -/-; Ext8C: embryonic day 9.5; Chp1em1(IMPC)Tcp/Chp1em1(IMPC)Tcp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6C Chp1-/- MCT4 , 6C Chp1-/- Merge , Extended Data 8C -/- #2 Merge , Extended Data 8C -/- #2 MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen 6D Exoc3l4 +/-; Ext20E: embryonic day 10.5; Exoc3l4em1(IMPC)J/Exoc3l4+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6D Exoc3l4+/- Merge , 6D Exoc3l4+/- MCT4 , Extended Data 20E +/- MCT4 , Extended Data 20E +/- Merge Expression is seen in mature SynTII cells.
Specimen 6D Exoc3l4 -/-; Ext20E: embryonic day 10.5; Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6D Exoc3l4-/- Merge , Extended Data 20E -/- Merge , 6D Exoc3l4-/- MCT4 , Extended Data 20E -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII development was severely impaired.
Specimen 6E Usb1 +/-; Ext22F: embryonic day 10.5; Usb1em1(IMPC)Bay/Usb1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6E Usb1+/- Merge , Extended Data 22F +/- Merge , Extended Data 22F +/- MCT4 , 6E Usb1+/- MCT4 Expression is seen in mature SynTII cells.
Specimen 6E Usb1 -/-; Ext22F: embryonic day 10.5; Usb1em1(IMPC)Bay/Usb1em1(IMPC)Bay (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6E Usb1-/- Merge , Extended Data 22F -/- Merge , 6E Usb1-/- MCT4 , Extended Data 22F -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII development was severely decreased; expression is sparse and remains at the chorioallantoic interface.
Specimen 6F Traf7 -/-; Ext19F: embryonic day 10.5; Traf7em1(IMPC)Tcp/Traf7em1(IMPC)Tcp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted 6F Traf7-/- Merge , Extended Data 19F -/- MCT4 , Extended Data 19F -/- Merge , 6F Traf7-/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII development is nearly absent; expression is sparse.
Specimen Atp1b1 +/- E9.5: embryonic day 9.5; Atp1b1em1(IMPC)Mbp/Atp1b1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 2C +/- MCT4 , Extended Data 2C +/- Merge Expression is seen in mature SynTII cells.
Specimen Atp1b1 -/- E9.5: embryonic day 9.5; Atp1b1em1(IMPC)Mbp/Atp1b1em1(IMPC)Mbp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 2C -/- MCT4 , Extended Data 2C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls. (A slight reduction in the SynTII layer was observed but was attributed to the developmental delay of the conceptus.)
Specimen Ehbp1 +/- E9.5: embryonic day 9.5; Ehbp1em1(IMPC)J/Ehbp1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 3C +/- Merge , Extended Data 3C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Ehbp1 -/- E9.5: embryonic day 9.5; Ehbp1em1(IMPC)J/Ehbp1em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 3C -/- MCT4 , Extended Data 3C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls. (A slight reduction in the SynTII layer was observed but was attributed to the developmental delay of the conceptus.)
Specimen Tedc2 +/- E9.5: embryonic day 9.5; Tedc2em1(IMPC)J/Tedc2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 4C +/- MCT4 , Extended Data 4C +/- Merge Expression is seen in mature SynTII cells.
Specimen Tedc2 -/- E9.5: embryonic day 9.5; Tedc2em1(IMPC)J/Tedc2em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 4C -/- Merge , Extended Data 4C -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls. (A slight reduction in the SynTII layer was observed but was attributed to the developmental delay of the conceptus.)
Specimen Zmym2 +/- E9.5: embryonic day 9.5; Zmym2em1(IMPC)J/Zmym2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 5C +/- MCT4 , Extended Data 5C +/- Merge Expression is seen in mature SynTII cells.
Specimen Zmym2 -/- E9.5: embryonic day 9.5; Zmym2em1(IMPC)J/Zmym2em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 5C -/- MCT4 , Extended Data 5C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls.
Specimen Gcn1 +/- E9.5: embryonic day 9.5; Gcn1em1(IMPC)J/Gcn1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 6C +/- MCT4 , Extended Data 6C +/- Merge Expression is seen in mature SynTII cells.
Specimen Gcn1 -/- E9.5 - #1: embryonic day 9.5; Gcn1em1(IMPC)J/Gcn1em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 6C -/- #1 Merge , Extended Data 6C -/- #1 MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Gcn1 -/- E9.5 - #2: embryonic day 9.5; Gcn1em1(IMPC)J/Gcn1em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 6C -/- #2 MCT4 , Extended Data 6C -/- #2 Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Slc30a9 +/- E9.5: embryonic day 9.5; Slc30a9em1(IMPC)Bay/Slc30a9+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 7D +/- MCT4 , Extended Data 7D +/- Merge Expression is seen in mature SynTII cells.
Specimen Slc30a9 -/- E9.5: embryonic day 9.5; Slc30a9em1(IMPC)Bay/Slc30a9em1(IMPC)Bay (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 7D -/- Merge , Extended Data 7D -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Chp1 -/- E9.5 - #1: embryonic day 9.5; Chp1em1(IMPC)Tcp/Chp1em1(IMPC)Tcp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 8C -/- #1 MCT4 , Extended Data 8C -/- #1 Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Ppox +/- E9.5: embryonic day 9.5; Ppoxem1(IMPC)J/Ppox+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 9C +/- Merge , Extended Data 9C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Ppox -/- E9.5: embryonic day 9.5; Ppoxem1(IMPC)J/Ppoxem1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 9C -/- Merge , Extended Data 9C -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Urm1 +/- E9.5: embryonic day 9.5; Urm1em1(IMPC)J/Urm1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 10C +/- MCT4 , Extended Data 10C +/- Merge Expression is seen in mature SynTII cells.
Specimen Urm1 -/- E9.5: embryonic day 9.5; Urm1em1(IMPC)J/Urm1em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 10C -/- Merge , Extended Data 10C -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Kctd5 +/- E9.5: embryonic day 9.5; Kctd5em1(IMPC)J/Kctd5+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 12C +/- Merge , Extended Data 12C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Kctd5 -/- E9.5: embryonic day 9.5; Kctd5em1(IMPC)J/Kctd5em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 12C -/- MCT4 , Extended Data 12C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII differentiation initiate but fail to further elongate and undergo secondary branching.
Specimen Rprd2 +/- E9.5: embryonic day 9.5; Rprd2em1(IMPC)J/Rprd2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 13C +/- Merge , Extended Data 13C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Rprd2 -/- E9.5: embryonic day 9.5; Rprd2em1(IMPC)J/Rprd2em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 13C -/- MCT4 , Extended Data 13C -/- Merge In the mutant ectopic expression is seen along the entire chorioallantoic interface.
TS15: allantois Present Single cells Extended Data 13C -/- MCT4 , Extended Data 13C -/- Merge
Specimen Arpc1a +/- E9.5: embryonic day 9.5; Arpc1aem1(IMPC)J/Arpc1a+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 15C +/- Merge , Extended Data 15C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Arpc1a -/- E9.5: embryonic day 9.5; Arpc1aem1(IMPC)J/Arpc1aem1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 15C -/- MCT4 , Extended Data 15C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls.
Specimen Arpc1a +/- E10.5: embryonic day 10.5; Arpc1aem1(IMPC)J/Arpc1a+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 15F +/- Merge , Extended Data 15F +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Arpc1a -/- E10.5: embryonic day 10.5; Arpc1aem1(IMPC)J/Arpc1aem1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 15F -/- MCT4 , Extended Data 15F -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is nearly absent; expression is sparse and remains at the chorioallantoic interface.
Specimen Alg3 +/- E9.5: embryonic day 9.5; Alg3em1(IMPC)J/Alg3+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 16C +/- Merge , Extended Data 16C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Alg3 -/- E9.5: embryonic day 9.5; Alg3em1(IMPC)J/Alg3em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 16C -/- Merge , Extended Data 16C -/- MCT4 Expression is seen in mature SynTII cells; in mutants there is a lack of chorioallantoic elongation and secondary branching.
Specimen Alg3 +/- E10.5: embryonic day 10.5; Alg3em1(IMPC)J/Alg3+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 16F +/- Merge , Extended Data 16F +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Alg3 -/- E10.5: embryonic day 10.5; Alg3em1(IMPC)J/Alg3em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 16F -/- MCT4 , Extended Data 16F -/- Merge Expression is seen in mature SynTII cells; in mutants chorioallantoic branching and SynTII layer formation is severely impaired as demonstrated by limited expression.
Specimen Bltp2 +/- E9.5: embryonic day 9.5; Bltp2em1(IMPC)J/Bltp2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 17C +/- Merge , Extended Data 17C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Bltp2 -/- E9.5: embryonic day 9.5; Bltp2em1(IMPC)J/Bltp2em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 17C -/- Merge , Extended Data 17C -/- MCT4 Expression is seen in mature SynTII cells; in some mutants this layer was slightly delayed compared to that seen in controls, but this phenotype was not consistently observed.
Specimen Bltp2 +/- E10.5: embryonic day 10.5; Bltp2em1(IMPC)J/Bltp2+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 17F +/- Merge , Extended Data 17F +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Bltp2 -/- E10.5: embryonic day 10.5; Bltp2em1(IMPC)J/Bltp2em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 17F -/- MCT4 , Extended Data 17F -/- Merge Expression is seen in mature SynTII cells; in 3 of 4 examined mutants chorioallantoic branching and SynTII layer formation is impaired.
Specimen Stt3b +/- E9.5: embryonic day 9.5; Stt3bem1(IMPC)J/Stt3b+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 18C +/- Merge , Extended Data 18C +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Stt3b -/- E9.5: embryonic day 9.5; Stt3bem1(IMPC)J/Stt3bem1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 18C -/- MCT4 , Extended Data 18C -/- Merge Expression is seen in mature SynTII cells; in mutants chorioallantoic branching and SynTII layer formation is severely impaired.
Specimen Stt3b +/- E10.5: embryonic day 10.5; Stt3bem1(IMPC)J/Stt3b+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 18F +/- MCT4 , Extended Data 18F +/- Merge Expression is seen in mature SynTII cells.
Specimen Stt3b -/- E10.5: embryonic day 10.5; Stt3bem1(IMPC)J/Stt3bem1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 18F -/- MCT4 , Extended Data 18F -/- Merge Expression is seen in mature SynTII cells; in mutants chorioallantoic branching and SynTII layer formation is severely impaired.
Specimen Traf7 +/- E9.5: embryonic day 9.5; Traf7em1(IMPC)Tcp/Traf7+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 19C +/- MCT4 , Extended Data 19C +/- Merge Expression is seen in mature SynTII cells.
Specimen Traf7 -/- E9.5: embryonic day 9.5; Traf7em1(IMPC)Tcp/Traf7em1(IMPC)Tcp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 19C -/- MCT4 , Extended Data 19C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls.
Specimen Exoc3l4 +/- E9.5: embryonic day 9.5; Exoc3l4em1(IMPC)J/Exoc3l4+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 20C +/- MCT4 , Extended Data 20C +/- Merge Expression is seen in mature SynTII cells.
Specimen Exoc3l4 -/- E9.5: embryonic day 9.5; Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 20C -/- Merge , Extended Data 20C -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls.
Specimen Pgm1 +/- E9.5: embryonic day 9.5; Pgm1em1(IMPC)J/Pgm1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 21C +/- MCT4 , Extended Data 21C +/- Merge Expression is seen in mature SynTII cells.
Specimen Pgm1 -/- E9.5: embryonic day 9.5; Pgm1em1(IMPC)J/Pgm1em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 21C -/- MCT4 , Extended Data 21C -/- Merge Expression is seen in mature SynTII cells; in mutants chorioallantoic branching and SynTII layer formation is impaired.
Specimen Pgm1 +/- E10.5: embryonic day 10.5; Pgm1em1(IMPC)J/Pgm1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 21F +/- Merge , Extended Data 21F +/- MCT4 Expression is seen in mature SynTII cells.
Specimen Pgm1 -/- E10.5: embryonic day 10.5; Pgm1em1(IMPC)J/Pgm1em1(IMPC)J (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 21F -/- Merge , Extended Data 21F -/- MCT4 Expression is seen in mature SynTII cells; in mutants expression is sparse as chorioallantoic branching and SynTII layer formation is nearly absent.
Specimen Usb1 +/- E9.5: embryonic day 9.5; Usb1em1(IMPC)Bay/Usb1+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 22C +/- MCT4 , Extended Data 22C +/- Merge Expression is seen in mature SynTII cells.
Specimen Usb1 -/- E9.5: embryonic day 9.5; Usb1em1(IMPC)Bay/Usb1em1(IMPC)Bay (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 22C -/- Merge , Extended Data 22C -/- MCT4 Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls.
Specimen Tgds +/- E9.5: embryonic day 9.5; Tgdsem1(IMPC)Mbp/Tgds+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 23C +/- MCT4 , Extended Data 23C +/- Merge Expression is seen in mature SynTII cells.
Specimen Tgds -/- E9.5: embryonic day 9.5; Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS15: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 23C -/- MCT4 , Extended Data 23C -/- Merge Expression is seen in mature SynTII cells; in the mutant chorioallantoic branching and SynTII layer formation is comparable to that seen in controls.
Specimen Tgds +/- E10.5: embryonic day 10.5; Tgdsem1(IMPC)Mbp/Tgds+ (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 23F +/- MCT4 , Extended Data 23F +/- Merge Expression is seen in mature SynTII cells.
Specimen Tgds -/- E10.5: embryonic day 10.5; Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp (more )
Note: Multi-labeled: white - Slc16a3; red - Emcn (assay MGI:8351304); green - Slc16a1 (assay MGI:8350550); blue - DAPI.
Structure Cell Type Level Pattern Image Note
TS17: labyrinthine zone syncytiotrophoblast cell Present Regionally restricted Extended Data 23F -/- Merge , Extended Data 23F -/- MCT4 Expression is seen in mature SynTII cells; in mutants expression is sparse and remains at the chorioallantoic interface.
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09/15/2026
MGI 6.29 		The Jackson Laboratory