Gene Expression Image Detail
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Reference
Figure
ID
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J:386951
Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
Extended Data 23
MGI:8377029
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| Caption | (A) Summary of defects observed in E9.5 and E10.5 Tgds-/- placentas. (B) Histological images of adjacent sections from a representative E9.5 Tgds-/- placenta demonstrating normal development comparable to controls (n = 3). While Tpbp staining appears more intense in the displayed KO placenta compared to the control littermate, it is not consistent with all KO and control placentas examined. Dashed boxes indicate the LZ region shown at higher magnification in C. (D) Images of the embryonic component of the conceptuses shown in B and C. (E) Histological images of adjacent sections from a representative E10.5 Tgds-/- placenta displaying an abnormal chorioallantoic interface and multiple LZ defects relative to controls (n = 3). Dashed boxes indicate the LZ region shown at higher magnification in F. The abnormal chorioallantoic interface observed in the KO is characterized by a reduction in allantoic mesenchyme. In KO placentas, the Tfeb+ and MCT4+ SynTI region is reduced compared to controls. SynTII layer development/ chorioallantoic branching is nearly absent, as Gcm1 and MCT4 expression is sparse and remains at the chorioallantoic interface. Discrete fetal blood spaces and endothelial cells are not detected among labyrinth trophoblasts; instead, fetal blood cells remain in the non-invaded allantois. Large pools of maternal blood are observed adjacent to the LZ; however, integrated discrete maternal blood spaces are reduced. Although MCT1 and the more severely diminished MCT4 signals are found in close apposition, the extensive network of adjacent MCT1+ SynTI and MCT4+ SynTII cells observed in controls is absent. (G) Images of the embryonic component of the conceptuses shown in E and F. Scale bars: 500 m. |
| Copyright | This image is from Guertin TM, Development 2026 May 15;153(10):dev205276, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. |
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Associated Assays |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/15/2026 MGI 6.29 |
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