Gene Expression Image Detail
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Reference
Figure
ID
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J:386951
Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
Extended Data 13
MGI:8377017
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| Caption | (A) Summary of defects observed in E9.5 Rprd2-/- placentas. (B) Histological images of adjacent sections from a representative E9.5 Rprd2-/- placenta displaying a diminished Tpbp+ SpT layer, abnormal chorioallantoic interface, and multiple LZ defects relative to controls (n = 3). Dashed boxes indicate the LZ region shown at higher magnification in C. An abnormal chorioallantoic interface is observed in KO placentas, characterized by a reduced amount of allantoic mesenchyme and limited interface expansion. The Tfeb+ and MCT1+ SynTI region fails to expand and remains a thin layer compared to controls. The absence of allantois invasion and minimal Gcm1 expression indicate a complete failure of chorioallantoic branching and SynTII differentiation. MCT4 is ectopically expressed along the entire chorioallantoic interface and in the allantois. Fetal blood cells remain confined to the allantoic mesenchyme. While not clear in the representative image shown, Endomucin signal is observed in the allantois. Maternal blood also fails to integrate among labyrinth trophoblasts and instead accumulates between the JZ and LZ. Although the minimal MCT1 and MCT4 signals are found in close apposition, the extensive network of adjacent MCT1+ SynTI and MCT4+ SynTII cells observed in controls has not developed. (D) Images of the embryonic component of the conceptuses shown in B and C. (E) Examination of additional KO placentas demonstrates that a normal Pl-1+ TGC layer accompanies the diminished Tpbp+ SpT layer (n = 3). Scale bars: 500 m. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Copyright | This image is from Guertin TM, Development 2026 May 15;153(10):dev205276, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Associated Assays |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/15/2026 MGI 6.29 |
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