Gene Expression Image Detail

Reference

Figure

ID

J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276

Extended Data 5

MGI:8377008

Image

Caption

(A) Summary of the defects observed in E9.5 Zmym2-/- placentas. The patterned overlay indicates the phenotype is observed in at least half but not all KO placentas examined. (B) Histological images of adjacent sections from a representative E9.5 Zmym2-/- placenta displaying an expanded Tpbp + SpT layer relative to controls (n = 4). Dashed boxes indicate the LZ region shown at higher magnification in C. (D) Images of the embryonic component of the conceptuses shown in B and C. (E) Examination of additional KO placentas reveals a normal Pl-1+ TGC layer but variable SpT development (n= 3 normal, n = 1 reduced), in contrast to the previously examined KO placentas exhibiting an expanded SpT layer. Scale bars: 500 m.

Copyright

This image is from Guertin TM, Development 2026 May 15;153(10):dev205276, and is displayed under the terms of the Creative Commons Attribution 4.0 International License.

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
B +/- Gcm1	MGI:8350479 (Gcm1)
B -/- Gcm1	MGI:8350479 (Gcm1)
B +/- Tfeb	MGI:8350480 (Tfeb)
B -/- Tfeb	MGI:8350480 (Tfeb)
B +/- Tpbpa	MGI:8350481 (Tpbpa)
B -/- Tpbpa	MGI:8350481 (Tpbpa)
C +/- Gcm1	MGI:8350479 (Gcm1)
C -/- Gcm1	MGI:8350479 (Gcm1)
C +/- MCT1	MGI:8350550 (Slc16a1)
C -/- MCT1	MGI:8350550 (Slc16a1)
C +/- MCT4	MGI:8350556 (Slc16a3)
C -/- MCT4	MGI:8350556 (Slc16a3)
C +/- Merge	MGI:8351304 (Emcn) MGI:8350550 (Slc16a1) MGI:8350556 (Slc16a3)
C -/- Merge	MGI:8351304 (Emcn) MGI:8350550 (Slc16a1) MGI:8350556 (Slc16a3)
C +/- Tfeb	MGI:8350480 (Tfeb)
C -/- Tfeb	MGI:8350480 (Tfeb)
E +/- Pl-1	MGI:8350553 (Prl3d1)
E -/- Pl-1	MGI:8350553 (Prl3d1)
E +/- Tpbpa	MGI:8350481 (Tpbpa)
E -/- Tpbpa	MGI:8350481 (Tpbpa)