Exoc3l4^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Exoc3l4^em1(IMPC)J
• Name: exocyst complex component 3-like 4; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6294137
• Synonyms: Exoc3l4^-
• Gene: Exoc3l4 Location: Chr12:111383864-111398114 bp, + strand Genetic Position: Chr12, 60.98 cM, cytoband F2
• Alliance: Exoc3l4^em1(IMPC)J page
• IMPC: Exoc3l4 gene page

By E10.5 most Exoc3l4^em1(IMPC)J/Exoc3l4^em1(IMPC)J (Exoc3l4-/-) embryos are smaller, some are developmentally delayed, about half have abnormal hearts with some also having pericardial edema while others have cardiac edema. Embryos start dying around E11.5.

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

Allele Type: Endonuclease-mediated (Null/knockout) Mutation: Intragenic deletion Mutation details: This allele was generated at The Jackson Laboratory using Cas9 and guides with spacer sequences AAGAGTCTAGATCACTCCAC and GGGAGTTGTTAGGACCCAGG that targeted exon(s) ENSMUSE00000116352.2 ENSMUSE00000116361.2. This resulted in deletion(s) of 592 bp (location: Chr12:111391557-111392148; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794) Inheritance: Not Specified

Strategy for the generation of the Exoc3l4^em1(IMPC)J allele.

Expression

In Mice Carrying this Mutation:	54 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Exoc3l4 Mutation: 23 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 6 reference(s)