About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Exoc3l4em1(IMPC)J
Name: exocyst complex component 3-like 4; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6294137
Synonyms: Exoc3l4-
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
By E10.5 most Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)J (Exoc3l4-/-) embryos are smaller, some are developmentally delayed, about half have abnormal hearts with some also having pericardial edema while others have cardiac edema. Embryos start dying around E11.5.Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)JC57BL/6NJ-Exoc3l4em1(IMPC)J/Mmjax
Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)J placentas at E10.5 exhibit multiple labyrinth zone defects, with reduced labyrinth trophoblast layer and impaired chorioallantoic branching. An abnormally large accumulation of maternal blood is seen adjacent to the labyrinth trophoblasts.Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)JC57BL/6NJ-Exoc3l4em1(IMPC)J/Mmjax
E10.5 Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)J embryos are smaller but have all 3 germ layers.Exoc3l4em1(IMPC)J/Exoc3l4em1(IMPC)JC57BL/6NJ-Exoc3l4em1(IMPC)J/Mmjax
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory