Phenotype Image Detail

Image

Caption

At E9.5, Exoc3l4^em1(IMPC)J/Exoc3l4^em1(IMPC)J (Exoc3l4-/-) placentas demonstrate largely normal development. However, an abnormally large accumulation of maternal blood is observed adjacent to the labyrinth trophoblasts. At E10.5, Exoc3l4-/- placentas exhibit multiple labyrinth zone defects compared to controls. In KO placentas, the Tfeb+ labyrinth trophoblast layer is markedly reduced and Gcm1+ chorioallantoic branching is impaired. An abnormally large accumulation of maternal blood is observed adjacent to the labyrinth trophoblasts. By E11.5, Exoc3l4-/- placentas show a more severe manifestation of the E10.5 defects.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Exoc3l4^em1(IMPC)J	exocyst complex component 3-like 4; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Exoc3l4^em1(IMPC)J/Exoc3l4^em1(IMPC)J	C57BL/6NJ-Exoc3l4^em1(IMPC)J/Mmjax