Exoc3l4 MGI Mouse Gene Detail - MGI:1921363 - exocyst complex component 3-like 4

Symbol

Exoc3l4
Name

exocyst complex component 3-like 4
Synonyms

1200009I06Rik, 1600013K19Rik

Feature Type

protein coding gene
IDs

MGI:1921363
NCBI Gene: 74190
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr12:111383864-111398114 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.98 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

451 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921363	protein coding gene	Chr12:111383451-111398114 (+)
129S1/SvImJ	ENSMUSG00200024876	protein coding gene	Chr12:103161694-103176349 (+)
A/J	ENSMUSG00195041894	protein coding gene	Chr12:105681755-105696416 (+)
AKR/J	ENSMUSG00220034030	protein coding gene	Chr12:103576821-103591480 (+)
BALB/cJ	ENSMUSG00180046078	protein coding gene	Chr12:104924773-104939426 (+)
C3H/HeJ	ENSMUSG00175032535	protein coding gene	Chr12:107493229-107507888 (+)
C57BL/6NJ	ENSMUSG00215044575	protein coding gene	Chr12:104197687-104212340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018131	protein coding gene	Chr12:105868497-105881719 (+)
CAST/EiJ	ENSTCUG00005038362	protein coding gene	Chr12:103677875-103692538 (+)
CBA/J	ENSMUSG00210030288	protein coding gene	Chr12:104554669-104569328 (+)
DBA/2J	ENSMUSG00185027086	protein coding gene	Chr12:106384616-106399275 (+)
FVB/NJ	ENSMUSG00205028920	protein coding gene	Chr12:103612212-103626867 (+)
JF1/MsJ	ENSUMUG00000020011	protein coding gene	Chr12:111148040-111162723 (+)
LP/J	ENSMUSG00230043544	protein coding gene	Chr12:113426285-113440938 (+)
NOD/ShiLtJ	ENSMUSG00190020483	protein coding gene	Chr12:81608783-81623442 (-)
NZO/HlLtJ	ENSMUSG00225042122	protein coding gene	Chr12:115174458-115189111 (+)
PWK/PhJ	ENSLUMG00010041196	protein coding gene	Chr12:104602284-104616922 (+)
SPRET/EiJ	ENSMSPG00010016721	protein coding gene	Chr12:106883397-106897428 (+)
WSB/EiJ	ENSIUOG00005032601	protein coding gene	Chr12:103589988-103604643 (+)

Human Ortholog

EXOC3L4, exocyst complex component 3 like 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EXOC3L4, exocyst complex component 3 like 4
Synonyms

C14orf73
Links

HGNC:20120

NCBI Gene ID: 91828

UniProt: Q17RC7
Chr Location

14q32.32; chr14:103094174-103110570 (+) GRCh38

MGI Vertebrate Homology

Exoc3l4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EXOC3L4
Gene Tree

Exoc3l4

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
3 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

5
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, abnormal hearts, some accompanied by cardiac or pericardial edema, placentation defects, and complete lethality during organogenesis. A minority exhibit embryonic growth retardation.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

620
Tissues

17
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

81
RefSeq

14
UniProt

8
CCDS

CCDS26177.1

Ensembl

ENSMUSG00000021280 (Evidence)
NCBI Gene

74190

			Length	Strain/Species	Flank
genomic	74190	NCBI Gene Model \| MGI Sequence Detail	14251	C57BL/6J	± kb
transcript	NM_001289487	RefSeq \| MGI Sequence Detail	3525	C57BL/6
polypeptide	Q6DIA2	UniProt \| EBI \| MGI Sequence Detail	721	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000032016 exocyst complex component 3-like protein 4

(term hierarchy)
InterPro Domains

IPR010326 Exocyst complex component EXOC3/Sec6

IPR042532 Exocyst complex component EXOC3/Sec6, C-terminal domain

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All nucleic 13

Genomic 1

cDNA 11

Primer pair 1

Microarray probesets 5

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MGI:1921440

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276

TSS for Exoc3l4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115261	Chr12:111383885-111383901 (+)	29 bp
Tssr115262	Chr12:111383920-111383927 (+)	60 bp
Tssr115263	Chr12:111384035-111384113 (+)	210 bp
Tssr115264	Chr12:111386918-111386971 (+)	3,081 bp
Tssr115265	Chr12:111387030-111387041 (+)	3,172 bp
Tssr115266	Chr12:111387881-111387890 (+)	4,022 bp
Tssr115267	Chr12:111387897-111387919 (+)	4,044 bp
Tssr115268	Chr12:111387925-111387938 (+)	4,068 bp
Tssr115269	Chr12:111387962-111387973 (+)	4,104 bp
Tssr115270	Chr12:111387979-111387995 (+)	4,123 bp
Tssr115271	Chr12:111389547-111389567 (+)	5,693 bp
Tssr115272	Chr12:111389682-111389698 (+)	5,826 bp
Tssr115273	Chr12:111395060-111395086 (+)	11,209 bp
Tssr115274	Chr12:111395463-111395544 (+)	11,640 bp
Tssr115275	Chr12:111395566-111395577 (+)	11,708 bp
Tssr115276	Chr12:111395592-111395606 (+)	11,735 bp
Tssr115277	Chr12:111395617-111395694 (+)	11,792 bp
Tssr115278	Chr12:111395717-111395734 (+)	11,862 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29