Kras
Gene Detail

Symbol Name ID

Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog MGI:96680

STS

D6Mit14

Synonyms

Ki-ras, K-ras, Kras2, Kras-2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

77.37 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(78)

Sequence Map

Chr6:145216699-145250239 bp, - strand From VEGA annotation of GRCm38   33541 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37990  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Kras

Human homologs

Human Homolog		KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NCBI Gene ID		3845
neXtProt AC		NX_P01116
Human Synonyms		C-K-RAS, KI-RAS, KRAS1, KRAS2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, NS, NS3, RASK2
Human Chr (Location)		12p12.1; chr12:25358180-25403854 (-)  GRCh37.p10
Disease Associations		(8) Diseases Associated with Human KRAS

Alleles and phenotypes

All alleles(33) : Targeted(14) Gene trapped(17) Other(2)
 

Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia. Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis.

 
Human Diseases Modeled Using Mouse Kras (7)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	actin cytoskeleton organization, cytokine-mediated signaling pathway, ...
Component	membrane, membrane raft, ...
Function	GDP binding, GMP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (247)    Tissues (89)    Images (11)
Theiler Stages: 2, 3, 14, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	18
Western blot	99
RT-PCR	130

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(10) cDNA(18) Primer pair(13) Other(6)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022179 (Evidence)
Ensembl Gene Model	ENSMUSG00000030265 (Evidence)
Entrez Gene	16653 (Evidence)
NIA Mouse Gene Index	U028025
Consensus CDS Project	CCDS20693.1
International Mouse Knockout Project Status	Kras

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022179	VEGA Gene Model | MGI Sequence Detail	33541	C57BL/6J
transcript	OTTMUST00000052667	VEGA | MGI Sequence Detail	1194	Not Applicable
polypeptide	OTTMUSP00000025007	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(52) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(30) : PCR(13) RFLP(17) SNPs(184 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR020849	Small GTPase superfamily, Ras type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000009442	GTPase KRas

References

(Earliest) J:6226 Scolnick EM, et al., Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5355-9
(Latest) J:195234 Baker DJ, et al., Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013 Jan;15(1):96-102
All references(511)

Other accession IDs

MGD-MRK-11597, MGD-MRK-11601, MGI:2141518