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Kras Gene Detail
Summary
  • Symbol
    Kras
  • Name
    Kirsten rat sarcoma viral oncogene homolog
  • Synonyms
    Ki-ras, K-ras, Kras2, Kras-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96680
    NCBI Gene: 16653
  • Gene Overview
    MyGene.info: KRAS
Location & Maps
more
  • Sequence Map
    Chr6:145216699-145250239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33541 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.37 cM, cytoband G2
  • Mapping Data
    78 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    KRAS, KRAS proto-oncogene, GTPase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRAS, KRAS proto-oncogene, GTPase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFC2, c-Ki-ras2, C-K-RAS, KI-RAS, KRAS1, KRAS2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, NS, NS3, RALD, RASK2
  • Links
    NCBI Gene ID: 3845
    neXtProt AC: NX_P01116
    UniProt: P01116

  • Chr Location
    12p12.1; chr12:25204789-25252093 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    6 with Kras mouse models; 8 with human KRAS associations

Human Disease Mouse Models
      
IDs
View 21 models
IDs
View 1 model
IDs
View 21 models
      
IDs
View 1 model
IDs
View 2 models
IDs
View 4 models
      
IDs
View 1 "NOT" model
IDs
View 4 models
IDs
IDs
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    11 with disease annotations
  • References
    110 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    209 phenotypes from 16 alleles in 50 genetic backgrounds
    220 phenotypes from multigenic genotypes
    4 images
    821 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia. Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022179 VEGA Gene Model | MGI Sequence Detail 33541 C57BL/6J ±  kb
transcript OTTMUST00000052667 VEGA | MGI Sequence Detail 1194 Not Applicable  
polypeptide OTTMUSP00000025007 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    244 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 48
    Genomic 10
    cDNA 19
    Primer pair 13
    Other 6

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11597, MGD-MRK-11601, MGI:2141518
References
more
  • Summaries
    All 965
    Developmental Gene Expression 16
    Diseases 110
    Gene Ontology 19
    Phenotypes 821
  • Earliest
    J:6226 Scolnick EM, et al., Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5355-9
  • Latest
    J:238407 Rajurkar M, et al., IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis. Cancer Res. 2017 Jan 15;77(2):320-329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory