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Kras
Gene Detail
 Symbol
Name
ID
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
MGI:96680
STS D6Mit14
Synonyms Ki-ras, K-ras, Kras2, Kras-2
Feature Type protein coding gene
Genetic Map
Chromosome 6
77.37 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(78)
Sequence Map
Chr6:145216699-145250239 bp, - strand
From VEGA annotation of GRCm38

  33541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37990  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Kras

Human
homologs
Human Homolog KRAS, Kirsten rat sarcoma viral oncogene homolog
NCBI Gene ID 3845
neXtProt AC  NX_P01116
Human Synonyms  CFC2, C-K-RAS, KI-RAS, KRAS1, KRAS2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, NS, NS3, RASK2
Human Chr (Location)  12p12.1; chr12:25205246-25250923 (-)  GRCh38
Disease Associations  (8) Diseases Associated with Human KRAS
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(17) Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia. Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis.
 
Human Diseases Modeled Using Mouse Kras (8)    Alleles Annotated to Human Diseases(5)   
Interactions
Kras interacts with 368 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process actin cytoskeleton organization, cytokine-mediated signaling pathway, ...
Component focal adhesion, intracellular, ...
Function GDP binding, GMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (247)    Tissues (99)    Images (12)
Theiler Stages: 2, 3, 14, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 18
Western blot 99
RT-PCR 130
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(10) cDNA(18) Primer pair(13) Other(6)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022179 (Evidence)
Ensembl Gene ModelENSMUSG00000030265 (Evidence)
Entrez Gene16653 (Evidence)
NIA Mouse Gene IndexU028025
Consensus CDS ProjectCCDS20693.1
International Mouse Knockout Project StatusKras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022179 VEGA Gene Model | MGI Sequence Detail 33541 C57BL/6J ±  kb
transcript OTTMUST00000052667 VEGA | MGI Sequence Detail 1194 Not Applicable 
polypeptide OTTMUSP00000025007 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(6)
Polymorphisms All PCR and RFLP(30) : PCR(13) RFLP(17) SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000009442 GTPase KRas
References (Earliest) J:6226 Scolnick EM, et al., Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5355-9
(Latest) J:211986 Belmont L, et al., Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer. Int J Cancer. 2014 Feb 15;134(4):765-77
All references(647)
Disease annotation references (30)
Other
accession IDs
MGD-MRK-11597, MGD-MRK-11601, MGI:2141518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory