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Kras Gene Detail
Summary
  • Symbol
    Kras
  • Name
    Kirsten rat sarcoma viral oncogene homolog
  • Synonyms
    Ki-ras, K-ras, Kras2, Kras-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96680
    NCBI Gene: 16653
  • Gene Overview
    MyGene.info: KRAS
Location & Maps
more
  • Sequence Map
    Chr6:145216699-145250239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33541 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 77.37 cM, cytoband G2
  • Mapping Data
    78 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    KRAS, KRAS proto-oncogene, GTPase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRAS, KRAS proto-oncogene, GTPase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CFC2, C-K-RAS, KI-RAS, KRAS1, KRAS2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, NS, NS3, RALD, RASK2
  • Links
    NCBI Gene ID: 3845
    neXtProt AC: NX_P01116

  • Chr Location
    12p12.1; chr12:25204789-25250931 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    8 with Kras mouse models; 9 with human KRAS associations

Human Disease Mouse Models
       Leukemia, Acute Myeloid; AML   OMIM: 601626 View 1 "NOT" model
Lung Cancer   OMIM: 211980 View 18 models
Noonan Syndrome 3; NS3   OMIM: 609942 View 1 model
Pancreatic Cancer   OMIM: 260350 View 19 models
       Endometriosis, Susceptibility to, 1   OMIM: 131200 View 1 model
Juvenile Myelomonocytic Leukemia; JMML   OMIM: 607785 View 2 models
Lung Cancer Susceptibility 3; LNCR3   OMIM: 612571 View 3 models
Prostate Cancer   OMIM: 176807 View 4 models
       Bladder Cancer   OMIM: 109800
Breast Cancer   OMIM: 114480 View 1 model
Cardiofaciocutaneous Syndrome 2; CFC2   OMIM: 615278
Gastric Cancer, Hereditary Diffuse; HDGC   OMIM: 137215
Schimmelpenning-Feuerstein-Mims Syndrome; SFM   OMIM: 163200
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    10 with disease annotations
  • References
    93 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    208 phenotypes from 16 alleles in 50 genetic backgrounds
    210 phenotypes from multigenic genotypes
    4 images
    751 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Gene trapped
    17
  • Targeted
    22
  • Transgenic
    9
  • Incidental Mutations
Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia. Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022179 VEGA Gene Model | MGI Sequence Detail 33541 C57BL/6J ±  kb
transcript OTTMUST00000052667 VEGA | MGI Sequence Detail 1194 Not Applicable  
polypeptide OTTMUSP00000025007 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    244 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000009442 GTPase KRas
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 48
    Genomic 10
    cDNA 19
    Primer pair 13
    Other 6

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11597, MGD-MRK-11601, MGI:2141518
References
more
  • Summaries
    All 835
    Developmental Gene Expression 16
    Diseases 93
    Gene Ontology 18
    Phenotypes 751
  • Earliest
    J:6226 Scolnick EM, et al., Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5355-9
  • Latest
    J:232399 Reynoird N, et al., Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes Dev. 2016 Apr 1;30(7):772-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory