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Phenotypes Associated with This Genotype
Genotype
MGI:5300204
Allelic
Composition
Krastm4Tyj/Kras+
Scribtm1.1Phum/Scribtm1.1Phum
Tg(Pbsn-cre)20Fwan/0
Genetic
Background
involves: 129S4/SvJae * FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Scribtm1.1Phum mutation (0 available); any Scrib mutation (53 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 3 of 10 mice exhibit signs of illness and were sacrificed prior to 400 days

reproductive system
• well-differentiated adenocarcinomas in 20% of mice
• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm
• 3 of 15 mice develop poorly differentiated invasive carcinoma
• well-differentiated adenocarcinomas in 20% of mice

digestive/alimentary system
• focal intestinal metaplasia

endocrine/exocrine glands
• well-differentiated adenocarcinomas in 20% of mice
• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory