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Scribtm1.1Phum
Targeted Allele Detail
Summary
Symbol: Scribtm1.1Phum
Name: scribbled planar cell polarity; targeted mutation 1.1, Patrick O Humbert
MGI ID: MGI:5299425
Synonyms: Scribfl
Gene: Scrib  Location: Chr15:75919011-75941633 bp, - strand  Genetic Position: Chr15, 35.29 cM
Alliance: Scribtm1.1Phum page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178461
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Flp-mediated recombination removed the neo cassette and left exons 4 through 13 floxed. (J:178461)
Generation of the Scribtm1.1Phum and Scribtm1.2Phum alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  53 strains or lines available
References
Original:  J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory