About   Help   FAQ
Targeted Allele Detail
Symbol: Scribtm1.1Phum
Name: scribbled planar cell polarity; targeted mutation 1.1, Patrick O Humbert
MGI ID: MGI:5299425
Synonyms: Scribfl
Gene: Scrib  Location: Chr15:75919011-75941633 bp, - strand  Genetic Position: Chr15, 35.29 cM
Alliance: Scribtm1.1Phum page
Germline Transmission:  Earliest citation of germline transmission: J:178461
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Flp-mediated recombination removed the neo cassette and left exons 4 through 13 floxed. (J:178461)
Generation of the Scribtm1.1Phum and Scribtm1.2Phum alleles
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  53 strains or lines available
Original:  J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory