Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Scribtm1.1Phum mutation
(0 available);
any
Scrib mutation
(53 available)
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neoplasm
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• 100% of mice develop lung lesions at 6 weeks post intranasal adenoviral cre (AdCre) administration, ranging from grades 1 to 3
• mice show accelerated lung tumorigenesis, with more advanced and higher-grade tumors post intranasal AdCre administration compared to single Kras heterozygotes
• a 2.9-fold increase in tumor burden compared to single Kras heterozygotes at 12 weeks post intranasal AdCre administration
• lung tumors from intranasally AdCre treated mice show enhanced stromal reactivity and inflammation
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respiratory system
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• 100% of mice develop lung lesions at 6 weeks post intranasal adenoviral cre (AdCre) administration, ranging from grades 1 to 3
• mice show accelerated lung tumorigenesis, with more advanced and higher-grade tumors post intranasal AdCre administration compared to single Kras heterozygotes
• a 2.9-fold increase in tumor burden compared to single Kras heterozygotes at 12 weeks post intranasal AdCre administration
• lung tumors from intranasally AdCre treated mice show enhanced stromal reactivity and inflammation
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Scribtm1.1Phum mutation
(0 available);
any
Scrib mutation
(53 available)
|
|
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neoplasm
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• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration
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respiratory system
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• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration
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• 100% of mice show epithelial hyperplasia at 6 weeks post intranasal AdCre administration
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Scribtm1.1Phum mutation
(0 available);
any
Scrib mutation
(53 available)
Tg(Pbsn-cre)20Fwan mutation
(1 available)
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mortality/aging
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• 3 of 10 mice exhibit signs of illness and were sacrificed prior to 400 days
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reproductive system
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• well-differentiated adenocarcinomas in 20% of mice
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• high-grade in 33% of mice
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• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice
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neoplasm
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• high-grade in 33% of mice
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• 3 of 15 mice develop poorly differentiated invasive carcinoma
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• well-differentiated adenocarcinomas in 20% of mice
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digestive/alimentary system
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• focal intestinal metaplasia
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endocrine/exocrine glands
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• well-differentiated adenocarcinomas in 20% of mice
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• high-grade in 33% of mice
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• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Scribtm1.1Phum mutation
(0 available);
any
Scrib mutation
(53 available)
Tg(Pbsn-cre)20Fwan mutation
(1 available)
|
|
|
reproductive system
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• well-differentiated adenocarcinomas in 13% of mice
|
|
• high-grade in 20% of mice
|
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• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice
|
neoplasm
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• well-differentiated adenocarcinomas in 13% of mice
|
|
• high-grade in 20% of mice
|
digestive/alimentary system
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• focal intestinal metaplasia
|
endocrine/exocrine glands
|
• well-differentiated adenocarcinomas in 13% of mice
|
|
• high-grade in 20% of mice
|
|
• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scribtm1.1Phum mutation
(0 available);
any
Scrib mutation
(53 available)
Tg(Pbsn-cre)20Fwan mutation
(1 available)
|
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reproductive system
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• 88% at 100 days, 75% at 200 days, and 90% at 400 days
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• increase in cell proliferation compared with control
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neoplasm
endocrine/exocrine glands
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• 88% at 100 days, 75% at 200 days, and 90% at 400 days
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• increase in cell proliferation compared with control
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