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Phenotypes Associated with This Genotype
Genotype
MGI:5013917
Allelic
Composition
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• all mutants develop pancreatic ductal adenocarcinoma by 3 weeks of age

endocrine/exocrine glands
• mutants show severe exocrine pancreatic atrophy and edema along with the presence of mPanINs, metaplasias, and ducto-insular complexes and pancreatic ductal adenocarcinoma at P17
• mutants exhibit acinar-to-ductal metaplasia
• all mutants develop pancreatic ductal adenocarcinoma by 3 weeks of age

homeostasis/metabolism
• pancreas at P1-P17 shows edema

mortality/aging
• mutants are moribound by weaning, with a median survival of about 17 days

digestive/alimentary system
• mutants show severe exocrine pancreatic atrophy and edema along with the presence of mPanINs, metaplasias, and ducto-insular complexes and pancreatic ductal adenocarcinoma at P17

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:164210


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory