Phenotypes for Cdk6 Kras Polr2a MGI:4844194 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdk6^tm1Bbd/Cdk6^tm1Bbd Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk6^tm1Bbd mutation (1 available); any Cdk6 mutation (39 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (69 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:161780 )

• 50% of tamoxifen-treated mice survive at 40 weeks

neoplasm

increased adenoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

increased lung non-small cell carcinoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

respiratory system

increased lung non-small cell carcinoma incidence ( J:161780 )

• in mice treated with tamoxifen at weaning

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:161780

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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