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Targeted Allele Detail
Symbol: Krastm4.1Bbd
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4.1, Mariano Barbacid
MGI ID: MGI:5649285
Synonyms: K-RasV14I
Gene: Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance: Krastm4.1Bbd page
Germline Transmission:  Earliest citation of germline transmission: J:223433
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA loxP site flanked hygromycin resistance gene and STOP cassette was inserted 100 bp upstream of a Kras mutagenized exon 2 in which valine codon 14 (GTA) was changed to isoleucine (ATA) (p.V14I). Cre-mediated recombination in the germline removed the floxed LSL cassette, allowing expression of the mutant allele. (J:223433)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 13 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Krastm4.1Bbd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  58 strains or lines available
Original:  J:223433 Hernandez-Porras I, et al., K-RasV14I recapitulates Noonan syndrome in mice. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory