Analysis Tools
mortality/aging
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• shortened life span, with a median survival time of 6 months and no mice surviving past 8 months of age
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• shortened life span due to lung tumors
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neoplasm
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• weekly exposure to aerosolized nontypeable Haemophilus influenzae lystate (NTHi) for 8 weeks to induce chronic obstructive pulmonary disease (COPD)-like chronic airway inflammation increases lung surface tumors 3.2-fold while no tumors are seen in NTHi treated wild-type mice
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• isolated small lesions in the lungs are seen in 1- and 2-month-old mice and an increase in lesion size is seen with age
• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen
• lesions are atypical papillary bronchiolar hyperplasia, solid and papillary adenomas, adenomas with atypical cytologic features, atypical papillary bronchiolar hyperplasia adjacent to adenomas, and adenoncarcinoma
• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages
• early lung lesions exhibit a Clara cell phenotype indicating that lesions come from Clara Cells of conducting airways and more advanced pathologies show an alveolar type II cell phenotype
• weekly exposure to aerosolized nontypable Haemophilus influenzae lysate results in an increase in total lung tumor burden
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• lesions include solid and papillary adenomas and adenomas with atypical cytologic features
• adenomas are predominately of the papillary subtype
• number of adenomas is greater than in Krastm4Tyj Scgb1a1tm1(cre)Fjd mice but the mean size of adenomas is smaller
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respiratory system
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• mice show elevated macrophage numbers in bronchoalveolar lavage fluid (BALF)
• 14-week-old mice show focal infiltration of macrophages around hyperplastic and adenomatous lesions
• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors
• mice exposed to aerosolized nontypeable Haemophilus influenzae lystate (NTHi) once weekly for 8 weeks to induce chronic obstructive pulmonary disease (COPD)-like chronic airway inflammation show dense infiltration of the lung parenchyma with macrophages, neutrophils, and lymphocytes indicating neutrophil/macrophage/CD8 T cell-associated COPD-like airway inflammation; the inflammatory infiltrate is centered around airways and blood vessels, but also extends widely into alveolar spaces
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• isolated small lesions in the lungs are seen in 1- and 2-month-old mice and an increase in lesion size is seen with age
• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen
• lesions are atypical papillary bronchiolar hyperplasia, solid and papillary adenomas, adenomas with atypical cytologic features, atypical papillary bronchiolar hyperplasia adjacent to adenomas, and adenoncarcinoma
• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages
• early lung lesions exhibit a Clara cell phenotype indicating that lesions come from Clara Cells of conducting airways and more advanced pathologies show an alveolar type II cell phenotype
• weekly exposure to aerosolized nontypable Haemophilus influenzae lysate results in an increase in total lung tumor burden
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• lesions include solid and papillary adenomas and adenomas with atypical cytologic features
• adenomas are predominately of the papillary subtype
• number of adenomas is greater than in Krastm4Tyj Scgb1a1tm1(cre)Fjd mice but the mean size of adenomas is smaller
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• in early stages, epithelial hyperplasia is only seen in bronchioles, not in the alveolar sac area
• lesions include atypical papillary bronchiolar hyperplasia and atypical papillary bronchiolar hyperplasia adjacent to adenomas
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immune system
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• mice show elevated macrophage numbers in bronchoalveolar lavage fluid (BALF)
• 14-week-old mice show focal infiltration of macrophages around hyperplastic and adenomatous lesions
• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors
• mice exposed to aerosolized nontypeable Haemophilus influenzae lystate (NTHi) once weekly for 8 weeks to induce chronic obstructive pulmonary disease (COPD)-like chronic airway inflammation show dense infiltration of the lung parenchyma with macrophages, neutrophils, and lymphocytes indicating neutrophil/macrophage/CD8 T cell-associated COPD-like airway inflammation; the inflammatory infiltrate is centered around airways and blood vessels, but also extends widely into alveolar spaces
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lung cancer | DOID:1324 |
OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 |
J:159271 | |
