Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Krastm4Tyj Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks MGI ID: MGI:2429948 Synonyms: caKRas, KR, Kras2tm14Tyj, Kras2tm4Tyj, KrasG12D, K-RasG12D, K-Ras(G12D)fl, K-RasL, KrasLox, K-rasLSL, KrasLSL-G12D, Lox-Stop-Lox-KrasG12D, LSL-KrasG12D, LSL-K-rasG12D, LSL-K-ras G12D, LSL-KrasG12D, LSL-Kras G12D Gene: Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2 Alliance: Krastm4Tyj page

Pancreatic tumors in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 and Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:73445
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutations:    Insertion, Single point mutation   Mutation details: Glycine codon 12 was changed to aspartic acid (p.G12D) to encode an oncogenic form of the KRAS2 protein. A loxP site flanked STOP cassette was included upstream of the inserted Kras2 sequence, such that the mutant transcript would be expressed only after Cre-mediated recombination. (J:73445)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	67 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	52 anatomical structure(s)

List all tumor models in MMHCdb carrying Krastm4Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	76 strains or lines available

Original:	J:73445 Jackson EL, et al., Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001 Dec 15;15(24):3243-8
All:	1395 reference(s)