Analysis Tools
mortality/aging
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• shortened life span, with a median survival time of 10 months and no mice surviving past 12 months of age
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• shortened life span due to lung tumors
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neoplasm
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• isolated small lesions in the lungs are seen in 4- and 6-month-old mice and an increase in lesion size is seen with age
• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen
• lesions are atypical papillary bronchiolar hyperplasia, solid and papillary adenomas, adenomas with atypical cytologic features, atypical papillary bronchiolar hyperplasia adjacent to adenomas, and adenoncarcinoma
• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages
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• lesions include solid and papillary adenomas and adenomas with atypical cytologic features
• adenomas are predominately of the papillary subtype
• number of adenomas is less than in Krastm4Tyj Scgb1a1tm1.1(cre)Fjd mice but the mean size of adenomas is greater
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• adenocarcinomas are only seen in the very late stage
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respiratory system
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• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors
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• isolated small lesions in the lungs are seen in 4- and 6-month-old mice and an increase in lesion size is seen with age
• however, no lesions are seen in other organs, including brain, liver, kidney, intestine, and muscle and no metastases are seen
• lesions are atypical papillary bronchiolar hyperplasia, solid and papillary adenomas, adenomas with atypical cytologic features, atypical papillary bronchiolar hyperplasia adjacent to adenomas, and adenoncarcinoma
• the main lesions are epithelial hyperplasia in the early stage and adenomas in the middle and late stages
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• lesions include solid and papillary adenomas and adenomas with atypical cytologic features
• adenomas are predominately of the papillary subtype
• number of adenomas is less than in Krastm4Tyj Scgb1a1tm1.1(cre)Fjd mice but the mean size of adenomas is greater
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• adenocarcinomas are only seen in the very late stage
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• lesions include atypical papillary bronchiolar hyperplasia and atypical papillary bronchiolar hyperplasia adjacent to adenomas
• in early stages, epithelial hyperplasia is only seen in bronchioles, not in the alveolar sac area
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immune system
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• focal to extensive acidophilic pneumonia is seen surrounding adenomas and adenocarcinomas in 30% of the total lung tumors
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lung cancer | DOID:1324 |
OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 |
J:159271 | |
