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Eef1a1tm1(Kras*)Arge
Targeted Allele Detail
Summary
Symbol: Eef1a1tm1(Kras*)Arge
Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Argiris Efstratiadis
MGI ID: MGI:3837679
Synonyms: Eef1a1-Kras*
Gene: Eef1a1  Location: Chr9:78385735-78389006 bp, - strand  Genetic Position: Chr9, 43.65 cM, cytoband E1
Alliance: Eef1a1tm1(Kras*)Arge page
Histology and immunophenotyping of mammary carcinomas in Eef1a1tm1(Kras*)Arge/Eef1a1+ Waptm1(cre)Arge/Wap+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146290
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Eef1a1tm1(Kras*)Arge expresses 1 gene
 
Mutation detailsA loxP site flanked neomycin resistance gene and STOP cassette was inserted along with a constitutively active Kras with the amino acid substitution of glycine with aspartic acid at position 12 (p.G12D) into intron 1. Cre-mediated removal of the STOP cassette is required to achieve expression of the constitutively active Kras. (J:146290)
Generation of the Eef1a1tm1(Kras*)Arge allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eef1a1 Mutation:  60 strains or lines available
References
Original:  J:146290 Klinakis A, et al., Igf1r as a therapeutic target in a mouse model of basal-like breast cancer. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2359-64
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory