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Targeted Allele Detail
Symbol: Eef1a1tm1(Kras*)Arge
Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Argiris Efstratiadis
MGI ID: MGI:3837679
Synonyms: Eef1a1-Kras*
Gene: Eef1a1  Location: Chr9:78385735-78389006 bp, - strand  Genetic Position: Chr9, 43.65 cM, cytoband E1
Alliance: Eef1a1tm1(Kras*)Arge page
Histology and immunophenotyping of mammary carcinomas in Eef1a1tm1(Kras*)Arge/Eef1a1+ Waptm1(cre)Arge/Wap+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:146290
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
Eef1a1tm1(Kras*)Arge expresses 1 gene
Mutation detailsA loxP site flanked neomycin resistance gene and STOP cassette was inserted along with a constitutively active Kras with the amino acid substitution of glycine with aspartic acid at position 12 (p.G12D) into intron 1. Cre-mediated removal of the STOP cassette is required to achieve expression of the constitutively active Kras. (J:146290)
Generation of the Eef1a1tm1(Kras*)Arge allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eef1a1 Mutation:  60 strains or lines available
Original:  J:146290 Klinakis A, et al., Igf1r as a therapeutic target in a mouse model of basal-like breast cancer. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2359-64
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory