Phenotypes Associated with This Genotype

Genotype
MGI:3770517

• Allelic Composition: Kras^tm3Tyj/Kras⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:68981 )

• Background Sensitivity: mean age at death is ~250 days on pure 129/Sv background compared to 200 days on mixed background

neoplasm

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

increased lung tumor incidence ( J:119477 )

• 100% of mice examined at 3-4 months of age have developed lung tumors

integument

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

respiratory system

increased lung tumor incidence ( J:119477 )

• 100% of mice examined at 3-4 months of age have developed lung tumors

hematopoietic system

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

immune system

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:68981