Trp53^tm1Gev
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Gev
• Name: transformation related protein 53; targeted mutation 1, Gerard I Evan
• MGI ID: MGI:3582594
• Synonyms: p53^ER, p53ER^TAM, p53ER^TAMKI, p53^KI, Trp53^KI
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Gev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99305
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The hormone-binding domain (encoding amino acids 281-599) of a modified estrogen receptor was fused in-frame at the 3' end of the coding sequence. Three new amino acids were introduced at the junction. A Floxed Neo cassette was inserted 580 bp down-stream from the polyadenylation site. The polyadenylation signal and other 3' untranslated sequences were left intact. (J:99305)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Gev

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:99305 Christophorou MA, et al., Temporal dissection of p53 function in vitro and in vivo. Nat Genet. 2005 Jul;37(7):718-26
• All: 31 reference(s)