Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1Gev
• Allele Name: targeted mutation 1, Gerard I Evan
• Allele ID: MGI:3582594
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Gev/Trp53^tm1Gev	involves: 129P2/OlaHsd * C57BL/6	MGI:3582657
cn2	Kras^tm4Tyj/Kras^+ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Gev/Trp53^tm1Gev	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5635880
cx3	Col1a1^tm1(tetO-URI1)Ndj/Col1a1^+ Tg(Cebpb-tTA)#Bjd/0 Trp53^tm1Gev/Trp53^+	B6.Cg-Trp53^tm1Gev Col1a1^tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd	MGI:6378452

Genotype
MGI:3582657

hm1

• Allelic Composition: Trp53^tm1Gev/Trp53^tm1Gev
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:99305 )

• high incidence and spectrum of spontaneous lymphoma

• most are lymphoid in nature, mainly malignant and metastatic thymic lymphomas

cellular

decreased cellular sensitivity to gamma-irradiation ( J:99305 )

• spleen, thymus and small intestinal epithelium exhibited gamma-irradiation induced apoptosis

• intraperitoneal administration of 4-hydrozytamoxifen restored radiosensitivity in as little as two hours

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:99305 )

• high incidence and spectrum of spontaneous lymphoma

• most are lymphoid in nature, mainly malignant and metastatic thymic lymphomas

Genotype
MGI:5635880

cn2

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)6Tuv/0; Trp53^tm1Gev/Trp53^tm1Gev
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:220300 )

• mice exhibit rapid development of pancreatic tumors within 8 weeks with features typical of human pancreatic adenocarcinoma

• tumors treated with ibrutinib show a reduction in proliferation rate and tumor fibrosis, inhibition of mast cell degranulation, and reduction in CD11b+ and F4/80+ macrophages and mice show increased survival

• mice treated with both ibrutinib and gemcitabine show extended survival compared to treatment with gemcitabine alone

• mice treated with a daily injection of cromolyn, a blocker of mast cell degranulation and inflammogen release, starting at 8 weeks of age show a reduction in F4/80+ cells and CD11b+ cells in the tumor stroma

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:220300 )

• mice exhibit rapid development of pancreatic tumors within 8 weeks with features typical of human pancreatic adenocarcinoma

• tumors treated with ibrutinib show a reduction in proliferation rate and tumor fibrosis, inhibition of mast cell degranulation, and reduction in CD11b+ and F4/80+ macrophages and mice show increased survival

• mice treated with both ibrutinib and gemcitabine show extended survival compared to treatment with gemcitabine alone

• mice treated with a daily injection of cromolyn, a blocker of mast cell degranulation and inflammogen release, starting at 8 weeks of age show a reduction in F4/80+ cells and CD11b+ cells in the tumor stroma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:220300

Genotype
MGI:6378452

cx3

• Allelic Composition: Col1a1^{tm1(tetO-URI1)Ndj}/Col1a1⁺; Tg(Cebpb-tTA)#Bjd/0; Trp53^tm1Gev/Trp53⁺
• Genetic Background: B6.Cg-Trp53^tm1Gev Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd

mortality/aging

premature death ( J:217463 )

• mice exhibit reduced survival compared to heterozygous Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd/0 mice

neoplasm

increased hepatocellular carcinoma incidence ( J:217463 )

• mice exhibit accelerated liver tumorigenesis compared to single heterozygous Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd/0 mice, with 80% of mice showing aggressive hepatocellular carcinoma

liver/biliary system

decreased hepatocyte apoptosis ( J:217463 )

• 8 week old mice show decreased cleaved caspase 3, Bax expression, collapsed fibers, Sirius Red staining and alanine transaminase levels, indicating suppressed hepatocyte apoptosis

increased hepatocellular carcinoma incidence ( J:217463 )

• mice exhibit accelerated liver tumorigenesis compared to single heterozygous Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd/0 mice, with 80% of mice showing aggressive hepatocellular carcinoma

cellular

decreased hepatocyte apoptosis ( J:217463 )

• 8 week old mice show decreased cleaved caspase 3, Bax expression, collapsed fibers, Sirius Red staining and alanine transaminase levels, indicating suppressed hepatocyte apoptosis