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Phenotypes Associated with This Genotype
Genotype
MGI:3836577
Allelic
Composition
Krastm1Bbd/Kras+
Tg(Pbsn-cre)4Prb/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (76 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 200 days, 100% of mice exhibit atypical hyperplasia unlike wild-type mice
• at 500 days, 93% of mice exhibit atypical hyperplasia unlike wild-type mice
• at 200 days, 67% of mice develop prostate intraepithelial neoplasia that display foci of small solid and cribiform intraluminal proliferation of atypical cells and nuclear atypia unlike wild-type mice
• at 500 days, 60% of mice exhibit prostate intraepithelial neoplasia unlike in wild-type mice

neoplasm
• at 200 days, 67% of mice develop prostate intraepithelial neoplasia that display foci of small solid and cribiform intraluminal proliferation of atypical cells and nuclear atypia unlike wild-type mice
• at 500 days, 60% of mice exhibit prostate intraepithelial neoplasia unlike in wild-type mice

endocrine/exocrine glands
• at 200 days, 100% of mice exhibit atypical hyperplasia unlike wild-type mice
• at 500 days, 93% of mice exhibit atypical hyperplasia unlike wild-type mice
• at 200 days, 67% of mice develop prostate intraepithelial neoplasia that display foci of small solid and cribiform intraluminal proliferation of atypical cells and nuclear atypia unlike wild-type mice
• at 500 days, 60% of mice exhibit prostate intraepithelial neoplasia unlike in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory