About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3032576
Allelic
Composition
Krastm4Tyj/Kras+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• pancreatic ductal adenocarcinomas (J:87973)
• transitions of epithelium from cuboid to columnar as early as 2 weeks (J:87973)
• extra pancreatic tumors are rare (J:87973)
• number and extent of lesions increases with age (J:87973)
• by 7-10 months occasional animals with invasive and metastatic adenocarcinomas (J:87973)
• lesions eventually found in liver diaphragm and lungs (J:87973)
• average cancer free survival is greater than 52 weeks and 2 of 9 mice develop pancreatic ductal adenocarcinoma (J:116130)
• pancreatic intraepithelial neoplasia (PanIN)-1 lesions are distributed widely throughout the pancreas, whereas PanIN-2 or -3 lesions are rarely seen

digestive/alimentary system
• 6 month old mice exhibit mild acinar cell loss

endocrine/exocrine glands
• 6 month old mice exhibit mild acinar cell loss
• pancreatic ductal adenocarcinomas (J:87973)
• transitions of epithelium from cuboid to columnar as early as 2 weeks (J:87973)
• extra pancreatic tumors are rare (J:87973)
• number and extent of lesions increases with age (J:87973)
• by 7-10 months occasional animals with invasive and metastatic adenocarcinomas (J:87973)
• lesions eventually found in liver diaphragm and lungs (J:87973)
• average cancer free survival is greater than 52 weeks and 2 of 9 mice develop pancreatic ductal adenocarcinoma (J:116130)
• pancreatic intraepithelial neoplasia (PanIN)-1 lesions are distributed widely throughout the pancreas, whereas PanIN-2 or -3 lesions are rarely seen

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:87973


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/14/2024
MGI 6.23
The Jackson Laboratory