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All mouse models of nervous system cancer with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | atypical teratoid rhabdoid tumor | Smarcb1tm1Gvk/Smarcb1tm1Gvk | involves: 129/Sv * C57BL/6J * SJL/J | J:101185 | View | |||
| atypical teratoid rhabdoid tumor | Smarcb1tm1Sho/Smarcb1+ | involves: 129S6/SvEvTac * C57BL/6J * DBA/2J | J:120820 | View | ||||
| atypical teratoid rhabdoid tumor |
Smarcb1tm1Sho/Smarcb1+ Tg(LPV-TAg121)2Tvd/0 |
involves: 129S6/SvEvTac * C57BL/6J * DBA/2J | J:120820 | View | ||||
| | glioblastoma |
Nf1tm1Fcr/Nf1tm1Fcr Trp53tm1Elee/Trp53tm1Elee Tg(GFAP-cre)25Mes/0 |
involves: 129S/SvEv * 129S4/SvJae * FVB/N | J:149662 | View | |||
| glioblastoma |
Trp53tm1Elee/Trp53tm1Tyj Tg(GFAP-cre)25Mes/0 |
involves: 129S2/SvPas * 129S4/SvJae * FVB/N | J:149662 | View | ||||
| medulloblastoma |
Cdkn1btm1Mlf/Cdkn1b+ Ptch1tm1Mps/Ptch1+ |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 | J:205254 | View | ||||
| medulloblastoma |
Cdkn1btm1Mlf/Cdkn1btm1Mlf Ptch1tm1Mps/Ptch1+ |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 | J:205254 | View | ||||
| medulloblastoma |
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd Ptch1tm1Mps/Ptch1+ |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ | J:102702 | View | ||||
| medulloblastoma |
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(Atoh1-cre)1Bfri/0 |
involves: 129T2/SvEms * C57BL/6 * CBA | J:139573 | View | ||||
| medulloblastoma |
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(Atoh1-cre/Esr1*)14Fsh/0 |
involves: 129T2/SvEms * FVB/N | J:139573 | View | ||||
| medulloblastoma |
Ptch1tm1Bjw/Ptch1tm1Bjw Tg(GFAP-cre)25Mes/0 |
involves: 129T2/SvEms * FVB/N | J:139573 | View | ||||
| medulloblastoma | Ptch1tm1Mps/Ptch1+ | involves: 129S1/Sv * 129X1/SvJ | J:144811 | View | ||||
| medulloblastoma |
Ptch1tm1Mps/Ptch1+ Ptch2tm1Pmc/Ptch2+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:112118 | View | ||||
| medulloblastoma |
Ptch1tm1Mps/Ptch1+ Ptch2tm1Pmc/Ptch2tm1Pmc |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:112118 | View | ||||
| medulloblastoma |
Ptch1tm1Mps/Ptch1+ Tg(Atoh1-GFP)1Jejo/? |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 | J:144811 | View | ||||
| medulloblastoma |
Ptch1tm1Mps/Ptch1+ Trp53tm1Tyj/Trp53tm1Tyj |
involves: 129 * 129S2/SvPas * C57BL/6 | J:67452 | View | ||||
| medulloblastoma | Ptch1tm1Zim/Ptch1+ | involves: 129 * CD-1 | J:79666 | View | ||||
| | familial meningioma |
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn Nf2tm2Gth/Nf2tm2Gth |
involves: 129P2/OlaHsd * FVB/N | J:131179 | View | |||
| medulloblastoma |
Brca2tm1Brn/Brca2tm1Brn Trp53tm1Tyj/Trp53+ Tg(Nes-cre)1Kln/0 |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL | J:144617 | View | ||||
| medulloblastoma |
Brca2tm1Brn/Brca2tm1Brn Trp53tm1Tyj/Trp53tm1Tyj Tg(Nes-cre)1Kln/0 |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL | J:144617 | View | ||||
| medulloblastoma |
SufuGt(XB699)Byg/Sufu+ Trp53tm1Tyj/Trp53tm1Tyj |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 | J:173443 | View | ||||
| retinoblastoma |
Rb1tm3Tyj/Rb1tm3Tyj Rbl1tm1Tyj/Rbl1tm1Tyj Tg(Pax6-cre,GFP)2Pgr/0 |
involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N | J:119919 | View | ||||
| retinoblastoma |
Rb1tm3Tyj/Rb1tm3Tyj Rbl2tm1Tyj/Rbl2tm1Tyj Tg(Nes-cre)1Atp/0 |
involves: 129S2/SvPas * 129S4/SvJae * FVB/N | J:91406 | View | ||||
| retinoblastoma |
Rb1tm3Tyj/Rb1tm3Tyj Rbl2tm2.1Tyj/Rbl2tm2.1Tyj Tg(Pax6-cre,GFP)2Pgr/0 |
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N | J:119919 | View | ||||
| Transgenes and Other Mutations | malignant astrocytoma |
Ptentm2.1Ppp/Ptentm2.1Ppp Tg(GFAP-TAg121)1Tvd/0 |
involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N | J:99385 | View | |||
| malignant astrocytoma | Tg(GFAP-Hras1)2Agu/Tg(GFAP-Hras1)2Agu | involves: 129S1/Sv * 129X1/SvJ * ICR | J:69129 | View | ||||
| malignant astrocytoma | Tg(GFAP-SRC)1Aag/0 | involves: C3H * C57BL/6 | J:40335 | View | ||||
| malignant astrocytoma | Tg(GFAP-SRC)2Aag/0 | involves: C3H * C57BL/6 | J:40335 | View | ||||
| malignant astrocytoma | Tg(GFAP-TAg121)1Tvd/0 | involves: C57BL/6 * DBA/2 * FVB/N | J:77132 | View | ||||
| medulloblastoma |
Tg(GFAP-tTA)67Pop/0 Tg(tetO-Ifng)184Pop/0 |
B6.Cg-Tg(GFAP-tTA)67Pop Tg(tetO-Ifng)184Pop | J:94092 | View | ||||
| medulloblastoma |
Tg(GFAP-tTA)67Pop/0 Tg(tetO-Ifng)184Pop/0 |
involves: 129S/SvEv * C57BL/6 * DBA/2 | J:94092 | View | ||||
| medulloblastoma | Tg(Neurod2-Smo*A1)199Jols/0 | C57BL/6-Tg(Neurod2-Smo*A1)199Jols | J:93861 | View | ||||
| medulloblastoma | Tg(Neurod2-Smo*A1)199Jols/0 | involves: C57BL/6 | J:221990 | View | ||||
| medulloblastoma | Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols | C57BL/6-Tg(Neurod2-Smo*A1)199Jols | J:189258 | View | ||||
| medulloblastoma | Tg(Neurod2-Smo*A2)#Jols/0 | C57BL/6-Tg(Neurod2-Smo*A2)#Jols | J:189258 | View | ||||
| medulloblastoma |
Tg(Slc1a2-tTA)#Waw/0 Tg(tetO-MYCN,-luc)#Waw/0 |
involves: FVB/NJ | J:160518 | View | ||||
| medulloblastoma |
Tg(Slc1a2-tTA)#Waw/0 Tg(tetO-MYCN,-luc)#Waw/Tg(tetO-MYCN,-luc)#Waw |
involves: FVB/NJ | J:160518 | View | ||||
| medulloblastoma | Tg(tetO-TAg,CMV-rtTA)123Yihu/0 | involves: FVB/N | J:141623 | View | ||||
| neuroblastoma |
Alktm1.1(ALK*F1174L)Heno/Alk+ Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0 |
involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL | J:294092 | View | ||||
| neuroblastoma |
Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0 |
involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL | J:294092 | View | ||||
| neuroblastoma |
Alktm1.1Ics/? Tg(Th-MYCN)41Waw/0 |
involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J | J:228124, J:261033 | View | ||||
| neuroblastoma |
Alktm2.1Ics/? Tg(Th-MYCN)41Waw/0 |
involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J | J:228124, J:261033 | View | ||||
| neuroblastoma |
Nf1tm1Tyj/Nf1+ Tg(Th-MYCN)41Waw/0 |
involves: 129S2/SvPas * BALB/c * C57BL/6J | J:41126 | View | ||||
| neuroblastoma |
Rb1tm1Tyj/Rb1+ Tg(Th-MYCN)41Waw/0 |
involves: 129S2/SvPas * BALB/c * C57BL/6J | J:41106 | View | ||||
| neuroblastoma |
Rettm2.1Cos/? Tg(Th-MYCN)41Waw/0 |
involves: 129S1/Sv * BALB/c * C57BL/6J | J:261033 | View | ||||
| neuroblastoma |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/0 Tg(Dbh-icre)1Gsc/0 |
involves: C57BL/6 * FVB/N | J:186696 | View | ||||
| neuroblastoma |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/0 Tg(Dbh-icre)1Gsc/0 Tg(Th-MYCN)41Waw/0 |
involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N | J:186696 | View | ||||
| neuroblastoma |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/0 Thtm1(cre)Te/Th+ |
involves: 129X1/SvJ * C57BL/6 * FVB/N | J:186696 | View | ||||
| neuroblastoma | Tg(OMP-SV40T)13Bse/0 | involves: C57BL/6 * SJL | J:54269 | View | ||||
| neuroblastoma | Tg(rTH-Tag)20Dmc/0 | involves: C57BL/6NTac * DBA/2NTac | J:90323 | View | ||||
| neuroblastoma | Tg(tetO-TAg)2-5Hiwa/0 | involves: C57BL/6 | J:156984, J:175962 | View | ||||
| neuroblastoma |
Tg(Th-ALK*F1174L)2Loch/0 Tg(Th-MYCN)41Waw/0 |
involves: 129X1/SvJ * BALB/c * C57BL/6J * CBA | J:191012 | View | ||||
| neuroblastoma | Tg(Th-MYCN)41Waw/0 | involves: 129X1/SvJ * BALB/c * C57BL/6J | J:172448 | View | ||||
| neuroblastoma | Tg(Th-MYCN)41Waw/0 | involves: BALB/c * C57BL/6J | J:41126 | View | ||||
| neuroblastoma | Tg(Th-MYCN)41Waw/0 | involves: BALB/c * C57BL/6J * FVB/N | J:141126 | View | ||||
| neuroblastoma |
Tg(Th-MYCN)41Waw/0 Trp53tm1Brd/Trp53+ |
involves: 129S7/SvEvBrd * BALB/c * C57BL/6J * FVB/N | J:41126 | View | ||||
| neuroblastoma | Tg(Th-MYCN)41Waw/Tg(Th-MYCN)41Waw | involves: BALB/c * C57BL/6J | J:41126 | View | ||||
| retinal cancer | Tg(Tyrp1-TAg)3434Bee/? | involves: BALB/c * C57BL/6J | J:75629 | View | ||||
| retinoblastoma | Tg(Pax6-TAg)1796Hur/0 | involves: FVB | J:196814 | View | ||||
| retinoblastoma | Tg(Rbp3-SV40)IT-2Jjw/? | involves: BALB/c * C57BL/6 | J:60231 | View | ||||
| retinoblastoma | Tg(TagRb)1Plm/? | involves: BALB/cJ * C57BL/6J | J:10320 | View | ||||
| uveal melanoma | Tg(Dct-Grm1)ESzc/0 | C57BL/6J-Tg(Dct-Grm1)ESzc | J:230115 | View | ||||
| Additional Complex Models | brain glioma |
Acvr1tm1Mak/Acvr1+ Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ H3c2tm1Mak/H3c2+ Olig2tm1.1(cre)Wdr/Olig2+ |
involves: 129 * C57BL/6 * FVB/N | J:285841 | View | |||
| brain glioma |
Acvr1tm1Mak/Acvr1+ Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Olig2tm1.1(cre)Wdr/Olig2+ |
involves: 129 * C57BL/6 * FVB/N | J:285841 | View | ||||
| central nervous system cancer |
Smarcb1tm2Sho/Smarcb1tm2Sho Trp53tm1Brn/Trp53tm1Brn Tg(GFAP-cre)#Gtm/0 |
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA | J:226786 | View | ||||
| glioblastoma proneural subtype |
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Trp53tm1Thl/Trp53tm1Thl Tyrc-Brd/Tyrc-Brd |
involves: 129/Sv * 129S4/SvJae * C57BL/6 | J:172585 | View | ||||
| glioblastoma proneural subtype |
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Tyrc-Brd/Tyrc-Brd |
involves: 129/Sv * 129S4/SvJae * C57BL/6 | J:172585 | View | ||||
| malignant astrocytoma |
Nf1tm1Par/Nf1+ Ptentm1Hwu/Pten+ Trp53tm1Tyj/Trp53+ Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
Nf1tm1Par/Nf1+ Trp53tm1Elee/Trp53+ Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
Nf1tm1Par/Nf1+ Trp53tm1Tyj/Trp53+ Tg(GFAP-cre)25Mes/0 |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N | J:134611 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(CBA/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
(SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 | J:64364 | View | ||||
| malignant astrocytoma |
Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+ |
B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ + | J:64364 | View | ||||
| malignant peripheral nerve sheath tumor |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Nf1tm1Tyj/Nf1+ |
involves: 129S2/SvPas * 129S6/SvEvTac | J:131914 | View | ||||
| malignant peripheral nerve sheath tumor |
Krastm4Tyj/Kras+ Ptentm1Hwu/Pten+ Tg(Gfap-cre)77.6Mvs/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd | J:154673 | View | ||||
| malignant peripheral nerve sheath tumor |
Ptentm2.1Ppp/Ptentm2.1Ppp Tg(Cnp-EGFR)10Nrat/0 Tg(Dhh-cre)1Mejr/0 |
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL | J:195067 | View | ||||
| medulloblastoma |
Cdkn2ctm1Bbd/Cdkn2c+ Trp53tm1Tyj/Trp53tm1Tyj |
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 | J:102702 | View | ||||
| medulloblastoma |
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd Trp53tm1Brn/Trp53tm1Tyj Tg(Nes-cre)1Kln/0 |
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL | J:102702 | View | ||||
| medulloblastoma |
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd Trp53tm1Tyj/Trp53tm1Tyj |
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 | J:102702 | View | ||||
| medulloblastoma |
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Olig2tm2(TVA,cre)Rth/Olig2+ |
involves: 129 * 129X1/SvJ | J:139574 | View | ||||
| medulloblastoma |
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Tg(Atoh1-cre/Esr1*)14Fsh/0 |
involves: 129X1/SvJ * FVB/N | J:139574 | View | ||||
| medulloblastoma |
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Tg(GFAP-cre)25Mes/0 |
involves: 129X1/SvJ * FVB/N | J:139574 | View | ||||
| medulloblastoma |
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc Tlx3tm1(cre)Qima/Tlx3+ |
involves: 129X1/SvJ | J:139574 | View | ||||
| medulloblastoma |
Lig4tm1Icrf/Lig4tm1Icrf Trp53tm1Tyj/Trp53tm1Tyj |
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ) | J:173443 | View | ||||
| medulloblastoma |
Ptentm2Mak/Ptentm2Mak Trp53tm1Brn/Trp53tm1Brn Tg(Nes-cre/ERT2,-ALPP)1Sbk/0 |
involves: 129P2/OlaHsd | J:237990 | View | ||||
| medulloblastoma |
Rag1tm1Mom/Rag1tm1Mom Trp53tm1Brd/Trp53tm1Brd Xrcc5tm1Dbr/Xrcc5tm1Dbr |
involves: 129S7/SvEvBrd * C57BL | J:141515 | View | ||||
| medulloblastoma |
Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brd/Trp53tm1Brd Tg(Gfap-cre)2Brn/0 |
involves: 129 * 129S7/SvEvBrd * FVB/N | J:61961 | View | ||||
| medulloblastoma |
Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn Tg(Gfap-cre)2Brn/0 |
involves: 129P2/OlaHsd * FVB/N | J:61961 | View | ||||
| medulloblastoma |
Trp53tm1Brd/Trp53tm1Brd Xrcc4tm2.1Fwa/Xrcc4tm2Fwa Tg(Nes-cre)1Kln/0 |
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * SJL | J:109585 | View | ||||
| neuroblastoma |
Gt(ROSA)26Sortm1(CAG-MYCN,-luc)Jhsc/Gt(ROSA)26Sor+ Tg(Dbh-icre)1Gsc/0 |
involves: 129S6/SvEvTac * C57BL/6 | J:222527 | View | ||||
| neuroblastoma |
Gt(ROSA)26Sortm2(CAG-Lin28b,-luc)Jhsc/Gt(ROSA)26Sor+ Tg(Dbh-icre)1Gsc/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 | J:241988 | View | ||||
| uveal melanoma |
Cdkn2atm1Rdp/Cdkn2a+ X/Tg(Tyr-HRAS)60Lc |
involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL | J:140820 | View | ||||
| uveal melanoma |
Gt(ROSA)26Sortm1(GNAQ*)Cvrk/Gt(ROSA)26Sor+ Tg(Mitf-cre)7114Gsb/0 |
C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvkr Tg(Mitf-cre)7114Gsb/Cvrk | J:225597 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | familial meningioma | Nf2tm1Tyj/Nf2+ | either: (involves: 129S2/SvPas * 129S4/SvJae * C57BL/6) or (involves: 129S2/SvPas * C57BL/6J) | J:47282 | View | |||