Phenotypes Associated with This Genotype

Genotype
MGI:6476981

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk^{tm1.1(ALK*F1174L)Heno}; Tg(Mpz-cre)94Imeg/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:294092 )

• mice show enhanced lethality compared to single Tg(Th-MYCN)41Waw expressing mice

neoplasm

increased neuroblastoma incidence ( J:294092 )

• mice develop neuroblastoma with earlier onset, higher penetrance and enhanced lethality than in single Tg(Th-MYCN)41Waw expressing mice

decreased tumor latency ( J:294092 )

• mice show earlier onset of neuroblastoma than in single Tg(Th-MYCN)41Waw expressing mice

nervous system

increased neuroblastoma incidence ( J:294092 )

• mice develop neuroblastoma with earlier onset, higher penetrance and enhanced lethality than in single Tg(Th-MYCN)41Waw expressing mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:294092