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Phenotypes Associated with This Genotype
Genotype
MGI:6414964
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (1046 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas

nervous system
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory