Phenotypes Associated with This Genotype

Genotype
MGI:6476983

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk⁺; Tg(Mpz-cre)94Imeg/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:294092 )

• mice that develop thoracic and/or abdominal tumors die by 6 months

neoplasm

increased neuroblastoma incidence ( J:294092 )

• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma

• 14 of 18 mice exhibit abdominal tumors

• 4 of 18 mice exhibit thoracic tumors

• 2 of 18 mice exhibit both abdominal and thoracic tumors

nervous system

increased neuroblastoma incidence ( J:294092 )

• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma

• 14 of 18 mice exhibit abdominal tumors

• 4 of 18 mice exhibit thoracic tumors

• 2 of 18 mice exhibit both abdominal and thoracic tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:294092