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Smarcb1tm1Sho
Targeted Allele Detail
Summary
Symbol: Smarcb1tm1Sho
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 1, Stuart Orkin
MGI ID: MGI:1931875
Synonyms: Snf5-
Gene: Smarcb1  Location: Chr10:75732603-75757448 bp, - strand  Genetic Position: Chr10, 38.61 cM
Alliance: Smarcb1tm1Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66417
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exon 1 of the Smarcb1 gene, including the initiation site. (J:66417)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Smarcb1tm1Sho
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarcb1 Mutation:  22 strains or lines available
References
Original:  J:66417 Roberts CW, et al., Haploinsufficiency of snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13796-800
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory