Alk^tm2.1Ics
Targeted Allele Detail

Summary

• Symbol: Alk^tm2.1Ics
• Name: anaplastic lymphoma kinase; targeted mutation 2.1, Mouse Clinical Institute
• MGI ID: MGI:5705326
• Synonyms: Alk^F1178L
• Gene: Alk Location: Chr17:72175967-72911622 bp, - strand Genetic Position: Chr17, 43.77 cM
• Alliance: Alk^tm2.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228124
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 23 was replaced with one in which a point mutation (TTC to CTC) that results in the amino acid substitution of leucine for phenyalanine at position 1178. This mutation corresponds to the F1174 identified in patients with neuroblastoma. Cre-mediated recombination removed the neomycin resistance cassette inserted downstream of the modified exon. (J:228124)

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alk Mutation: 62 strains or lines available

References

• Original: J:228124 Cazes A, et al., Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma. Oncotarget. 2014 May 15;5(9):2688-702
• All: 4 reference(s)