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Transgene Detail
Symbol: Tg(GFAP-TAg121)1Tvd
Name: transgene insertion 1, Terry Van Dyke
MGI ID: MGI:2445447
Synonyms: GdeltaZT121, G(deltaZ)T121, TgG(deltaZ)T121, Tg(GFAP-SV40T)2.1Tvd, Tg(GFAP-T121)2.1Tvd
Transgene: Tg(GFAP-TAg121)1Tvd  Location: unknown  
Alliance: Tg(GFAP-TAg121)1Tvd page
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThis allele was derived from mating Tg(GFAP-lacZ-TAg121)92Tvd animals to mice carrying a cre transgene (Tg(ACTB-cre)2Mrt). As a result the intervening floxed lacZ cassette was removed, leaving a single loxP site and allowing transcription from the mutant SV40 T antigen sequence. The mutant SV40 T antigen 121 contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. The mutant antigen binds RB1/RBL1/RBL2 but not TRP53. Immunohistochemical analysis of progeny showed diffuse expression of this transgene throughout the brain. (J:77132)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tg(GFAP-TAg121)1Tvd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:77132 Xiao A, et al., Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002 Mar;1(2):157-68
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory