Phenotypes Associated with This Genotype

Genotype
MGI:5286087

• Allelic Composition: Tg(GFAP-TAg121)1Tvd/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77132 )

• mice die at 5 to 8 months of age

nervous system

increased astrocytoma incidence ( J:77132 )

• malignant anaplastic

abnormal brain morphology ( J:77132 )

• at P7, mice exhibit increased periventriular cellularity compared with control mice but not as severe as in Tg(GFAP-SV40T)1Tvd mice

neoplasm

increased astrocytoma incidence ( J:77132 )

• malignant anaplastic

growth/size/body

weight loss ( J:77132 )

• at 1 to 3 months of age

craniofacial

abnormal cranium morphology ( J:77132 )

• bulging cranial at 1 to 3 months of age

skeleton

abnormal cranium morphology ( J:77132 )

• bulging cranial at 1 to 3 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant astrocytoma		DOID:3069		J:77132