Tg(GFAP-SV40T)1Tvd Transgene Detail MGI Mouse (MGI:2445446)

Tg(GFAP-SV40T)1Tvd
Transgene Detail

Summary

Symbol:	Tg(GFAP-SV40T)1Tvd
Name:	transgene insertion 1, Terry Van Dyke
MGI ID:	MGI:2445446
Synonyms:	TgGFAPT121, TgGFAP-T121, Tg(GFAP-T121)1Tvd
Transgene:	Tg(GFAP-SV40T)1Tvd Location: unknown
Alliance:	Tg(GFAP-SV40T)1Tvd page

Transgene
origin

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene
description

Transgene Type:		Transgenic (Inserted expressed sequence)
Mutation:		Insertion
		Mutation details: The transgene consists of a 2.2 kb fragment of human GFAP promoter, active in central nervous system cells of the astrocyte lineage, and a mutant SV40 T antigen sequence, which contains a deletion for the small t antigen-specific splice signal and a deletion resulting in truncation of the large T antigen at amino acid 121. Transgene expression in central nervous system cells of the astrocyte lineage was observed by immunohistochemical staining of brain sections from transgenic animals. (J:77132)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-SV40T)1Tvd

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

10 out of 13 founder animals developed severe brain abnormalities and died by 7-9 days of age. This transgene differs from Tg(GFAP-TAg121)1Tvd, which is a derivative of Tg(GFAP-lacZ-TAg121)92Tvd, and contains a loxP site in place of a Cre deleted lacZ cassette.

References

Original:	J:77132 Xiao A, et al., Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002 Mar;1(2):157-68
All:	1 reference(s)

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