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Phenotypes Associated with This Genotype
Genotype
MGI:5008634
Allelic
Composition		 Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (238 available)
Tyrc-Brd mutation (8 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172585 )
• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes

neoplasm
increased tumor growth/size ( J:172585 )
• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glioblastoma proneural subtype DOID:0050804 J:172585

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory