Phenotypes Associated with This Genotype

Genotype
MGI:8402593

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Nf1^tm1Fcr/Nf1⁺; Tg(Dhh-cre)1Mejr/0
• Genetic Background: B6.Cg-Cdkn2a^tm1Rdp Nf1^tm1Fcr Tg(Dhh-cre)1Mejr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:240370 )

• mice die by 10 months of age

• mice succumb to hematopoietic malignancies

neoplasm

increased neurofibrosarcoma incidence ( J:240370 )

• malignant peripheral nerve sheath tumors are evident typically at 4-6 months of age on the shoulders, ribs, or limbs, in the vicinity of peripheral nerves

increased hemolymphoid system tumor incidence ( J:240370 )

• mice develop hematopoietic neoplasms, with 44% of mice exhibiting hematopoietic malignancies

• mice succumb to hematopoietic malignancies, with enlarged liver and/or spleen

• hematopoietic malignancies typically occur in 6-8 months old mice

nervous system

increased neurofibrosarcoma incidence ( J:240370 )

• malignant peripheral nerve sheath tumors are evident typically at 4-6 months of age on the shoulders, ribs, or limbs, in the vicinity of peripheral nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant peripheral nerve sheath tumor		DOID:5940		J:240370