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Transgene Detail
Symbol: Tg(GFAP-SRC)2Aag
Name: transgene insertion 2, Adriano Aguzzi
MGI ID: MGI:2445477
Synonyms: src2
Transgene: Tg(GFAP-SRC)2Aag  Location: unknown  
Alliance: Tg(GFAP-SRC)2Aag page
Strain of Origin:  (C57BL/6J x C3H)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgene was constructed by insertion of a viral SRC cDNA sequence from the Schmidt-Ruppin strain into exon 1 of GFAP. The GFAP promoter drives expression of the transgene in astrocytes of the brain. RT-PCR analysis of brain RNA from transgenic animals confirmed expression of the transgene. Transgene expression was also detected in lung, thymus, spleen, and gonads. (J:40335)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tg(GFAP-SRC)2Aag
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Three transgenic lines were established. Lines src1 and src2 carry 5 and 32 copies, respectively, of the full-length SRC sequence whereas line src3 carries 8 copies of a 3' truncated SRC sequence.
Original:  J:40335 Weissenberger J, et al., Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice. Oncogene. 1997 May 1;14(17):2005-13
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory