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Tg(Nes-cre)1Atp
Transgene Detail
Summary
Symbol: Tg(Nes-cre)1Atp
Name: transgene insertion 1, Andreas Trumpp
MGI ID: MGI:2176835
Synonyms: Nes-Cre1, Nestincre, Nestin-Cre, Tg(Nes-cre)1Mrt
Transgene: Tg(Nes-cre)1Atp  Location: unknown  
Alliance: Tg(Nes-cre)1Atp page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Nes-cre)1Atp expression driven by 1 gene
 
Mutation detailsThe 5' region of the rat nestin gene was placed upstream of an NLS-Cre-pA and the rat nestin intron 2. This line carried a single or low copy transgene. The absence of transcript expression was confirmed by RT-PCR on endoneurial extracts. This promoter is active by E9 in the CNS progenitor cells. Transgene is paternally imprinted, thus brain-specific recombination is only 30% when allele is maternally inherited, compared to ~95% with paternal transmission (J:75417, J:121563). (J:58999, J:111945)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nes (rat)
Summary of all recombinase alleles driven by Nes.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 131 assay results
Tumor Data
List all tumor models in MMHCdb carrying Tg(Nes-cre)1Atp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:58999 Trumpp A, et al., Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 1;13(23):3136-48
All:  80 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory