Phenotypes Associated with This Genotype

Genotype
MGI:3776069

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Nf1^tm1Tyj/Nf1⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:131914 )

• virtually all mice die by 10 months of age

neoplasm

increased leukemia incidence ( J:131914 )

• seen in some mice

increased lymphoma incidence ( J:131914 )

• significant frequency of hematopoietic neoplasms consisting mainly of lymphomas and histiocytic neoplasms with lower incidences of acute myeloid leukemias and myeloproliferative disease

increased neurofibrosarcoma incidence ( J:131914 )

• developed in 26% of mice

• in most cases these tumors are grossly evident by 4 to 6 months of age

nervous system

nervous system phenotype ( J:131914 )

N • neural crest stem cells do not abnormally persist in the peripheral nervous system in adult mice

increased neurofibrosarcoma incidence ( J:131914 )

• developed in 26% of mice

• in most cases these tumors are grossly evident by 4 to 6 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant peripheral nerve sheath tumor		DOID:5940		J:131914