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All mouse models of intestinal disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | colorectal cancer | ApcMin/Apc+ | C57BL/6J-ApcMin | J:85142 | View | |||
| colorectal cancer |
ApcMin/Apc+ Ccdc80tm1.1Ftk/Ccdc80tm1.1Ftk |
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N | J:216704 | View | ||||
| colorectal cancer |
ApcMin/Apc+ Msh2tm1Mak/Msh2tm1Mak |
involves: 129P2/OlaHsd * C57BL/6J | J:75393, J:200824 | View | ||||
| colorectal cancer | Apctm1Cip/Apc+ | involves: 129P2/OlaHsd * C57BL/6 | J:94108 | View | ||||
| colorectal cancer |
Apctm1Mmt/Apc+ Smad4tm1Mmt/Smad4+ |
involves: 129S2/SvPas * C57BL/6 | J:46242 | View | ||||
| colorectal cancer |
Apctm1Rsmi/Apc+ Tg(Fabp1-cre)1Jig/0 |
involves: 129P2/OlaHsd * FVB/N | J:159883 | View | ||||
| colorectal cancer |
Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf/0 |
involves: 129S4/SvJae * C57BL/6 * SJL | J:126018 | View | ||||
| colorectal cancer |
Apctm2.1Cip/Apc+ Tg(Vil1-cre/ERT2)23Syr/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 | J:227287 | View | ||||
| colorectal cancer |
Apctm2Rak/Apc+ Krastm1.1Khai/Kras+ Tg(Fabp1-cre)1Jig/0 |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL | J:276349 | View | ||||
| colorectal cancer |
Apctm2Rak/Apc+ Krastm4Tyj/Kras+ Tg(Fabp1-cre)1Jig/0 |
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL | J:276349 | View | ||||
| colorectal cancer | Apctm2Rak/Apctm2Rak | involves: 129/Sv * C57BL/6J * SJL | J:156532 | View | ||||
| colorectal cancer |
Apctm2Rak/Apctm2Rak Krastm4Tyj/Kras+ |
involves: 129 * 129S4/SvJae * C57BL/6J * SJL | J:156532 | View | ||||
| Hirschsprung's disease | Edn3ls/Edn3ls | involves: C57BL | J:5008 | View | ||||
| Hirschsprung's disease | Edn3tm1Ywa/Edn3tm1Ywa | involves: 129S7/SvEvBrd | J:22207 | View | ||||
| Hirschsprung's disease | Ednrbs-l/Ednrbs-l | involves: C3H/HeJ * C57BL/6 | J:5008 | View | ||||
| Hirschsprung's disease | Ednrbtm1.1Nrd/Ednrbtm1.1Nrd | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:226561 | View | ||||
| Hirschsprung's disease |
Ednrbtm1Nrd/Ednrbtm1Nrd Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J | J:233811 | View | ||||
| Hirschsprung's disease | Ednrbtm1Ywa/Ednrbtm1Ywa | B6;129-Ednrbtm1Ywa/J | J:216833 | View | ||||
| Hirschsprung's disease | Ednrbtm1Ywa/Ednrbtm1Ywa | involves: 129S5/SvEvBrd | J:93622 | View | ||||
| Hirschsprung's disease | Gdnftm1Lmgd/Gdnf+ | either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1) | J:73922 | View | ||||
| Hirschsprung's disease | Gdnftm1Lmgd/Gdnftm1Lmgd | either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ) | J:33810 | View | ||||
| Hirschsprung's disease | Gdnftm1Rosl/Gdnf+ | involves: 129S2/SvPas * C57BL/6 | J:82456 | View | ||||
| Hirschsprung's disease | Rettm1Cos/Rettm1Cos | involves: 129S/Sv * C57BL/6 | J:135153 | View | ||||
| Hirschsprung's disease | Rettm1Cos/Rettm1Cos | involves: 129S/SvEv * MF1 | J:23852, J:30389 | View | ||||
| Hirschsprung's disease | Rettm1Cos/Rettm2(RET)Jmi | involves: 129S/Sv * C57BL/6 | J:135153 | View | ||||
| Hirschsprung's disease | Rettm2.1Heno/Rettm2.1Heno | involves: 129S/Sv * C57BL/6 * FVB/N | J:135153 | View | ||||
| inflammatory bowel disease | Il10tm1Cgn/Il10tm1Cgn | B6.129P2-Il10tm1Cgn/J | J:124308, J:149347 | View | ||||
| inflammatory bowel disease | Il10tm1Cgn/Il10tm1Cgn | involves: 129P2/OlaHsd * C57BL/6 | J:15222, J:35020 | View | ||||
| inflammatory bowel disease |
Il10tm1Cgn/Il10tm1Cgn Tg(MUC1)79.24Gend/0 |
B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend | J:149347 | View | ||||
| inflammatory bowel disease 10 | Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi | involves: 129P2/OlaHsd * C57BL/6 | J:141419 | View | ||||
| inflammatory bowel disease 10 | Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi | involves: 129P2/OlaHsd * C57BL/6 | J:141419 | View | ||||
| inflammatory bowel disease 13 | Abcb1atm1Bor/Abcb1atm1Bor | FVB.129P2-Abcb1atm1Bor/TacImx | J:51190 | View | ||||
| Peutz-Jeghers syndrome |
Amhr2tm3(cre)Bhr/Amhr2+ Stk11tm1Rdp/Stk11tm1Rdp |
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 | J:187754 | View | ||||
| Peutz-Jeghers syndrome | Stk11tm1.1Jish/Stk11+ | involves: 129S7/SvEvBrd * C57BL/6J | J:77213 | View | ||||
| Peutz-Jeghers syndrome | Stk11tm1.1Mlfr/Stk11+ | involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J | J:104347 | View | ||||
| Peutz-Jeghers syndrome |
Stk11tm1.1Mlfr/Stk11+ Trp53tm1Tyj/Trp53+ |
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J | J:104347 | View | ||||
| Peutz-Jeghers syndrome |
Stk11tm1.1Rdp/Stk11tm1.1Rdp Tg(KRT14-cre)1Ipc/0 |
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL | J:131037 | View | ||||
| Peutz-Jeghers syndrome |
Stk11tm1.1Rdp/Stk11tm1.1Rdp Tg(Pdx1-cre)89.1Dam/0 |
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N * ICR | J:134078 | View | ||||
| Peutz-Jeghers syndrome | Stk11tm1.2Rdp/Stk11+ | involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL | J:78818, J:131037 | View | ||||
| Peutz-Jeghers syndrome | Stk11tm1Tpm/Stk11+ | involves: 129S7/SvEvBrd * C57BL/6 * CD-1 | J:93361 | View | ||||
| Peutz-Jeghers syndrome | Stk11tm1Tpm/Stk11+ | Not Specified | J:79074 | View | ||||
| sitosterolemia | Abcg8tm1Elk/Abcg8tm1Elk | involves: 129S6/SvEvTac * C57BL/6J | J:94759 | View | ||||
| | colonic disease |
Sav1tm1.1Dupa/Sav1tm1.1Dupa Tg(Vil1-cre)997Gum/0 |
involves: 129P2/OlaHsd * C57BL/6J * SJL | J:165471 | View | |||
| colorectal cancer |
Stat3tm1Dlv/Stat3tm1Dlv Tg(Csf1r-icre)1Jwp/0 |
involves: 129P2/OlaHsd * C57BL/6 * FVB | J:156593 | View | ||||
| Crohn's disease | Efstm1Kale/Efstm1Kale | either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * C57BL/6J) | J:103757 | View | ||||
| Crohn's disease |
Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk Tg(Vil1-cre)20Syr/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 | J:193689 | View | ||||
| familial adenomatous polyposis | ApcM1Tno/Apc+ | either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl) | J:218227 | View | ||||
| familial adenomatous polyposis | ApcMin/Apc+ | C57BL/6J-ApcMin | J:86036 | View | ||||
| familial adenomatous polyposis | ApcMin/Apc+ | involves: AKR/J * C57BL/6J | J:830 | View | ||||
| familial adenomatous polyposis |
ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo |
B6.Cg-Rab25tm1Jrgo ApcMin | J:158733 | View | ||||
| familial adenomatous polyposis | Apctm1Cip/Apc+ | involves: 129P2/OlaHsd * C57BL/6 | J:94108 | View | ||||
| familial adenomatous polyposis |
Apctm1Kk/Apctm1Kk Tg(Lck-cre)1Cwi/? |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 | J:128606 | View | ||||
| familial adenomatous polyposis | Apctm1Mmt/Apc+ | involves: 129S2/SvPas * C57BL/6J | J:25200 | View | ||||
| familial adenomatous polyposis | Apctm1Rak/Apc+ | involves: 129P2/OlaHsd * C57BL/6 | J:20443 | View | ||||
| familial adenomatous polyposis | Apctm1Tno/Apctm1Tno | involves: 129S4/SvJae * C57BL/6 | J:43301 | View | ||||
| familial adenomatous polyposis | Apctm2Tno/Apc+ | involves: C57BL/6J | J:86036 | View | ||||
| Hirschsprung's disease | Aebp2Gt(BC0681)Wtsi/Aebp2+ | involves: 129P2/OlaHsd * C57BL/6 | J:177673 | View | ||||
| Hirschsprung's disease |
Erbb2tm1Klee/Erbb2tm1Klee Tg(Nes-cre)1Atp/0 |
involves: C57BL/6 * FVB/N | J:81239 | View | ||||
| Hirschsprung's disease | Gfra1tm1Jmi/Gfra1tm1Jmi | involves: 129X1/SvJ * C57BL/6 | J:49471 | View | ||||
| Hirschsprung's disease |
Gfra1tm1Jmi/Gfra1tm2Jmi Tg(CAG-cre/Esr1*)5Amc/0 |
involves: 129/Sv * C57BL/6 * CBA * SJL | J:122607 | View | ||||
| Hirschsprung's disease | Ihhtm1Amc/Ihhtm1Amc | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J | J:62158 | View | ||||
| Hirschsprung's disease |
Itgb1tm1Lscd/Itgb1tm1Ref Tg(PLAT-cre)116Sdu/0 |
involves: 129S1/Sv * 129X1/SvJ | J:108439 | View | ||||
| inflammatory bowel disease |
B2mtm1Unc/B2mtm1Unc Il2tm1Hor/Il2tm1Hor |
involves: 129 * C57BL/6 | J:51450 | View | ||||
| inflammatory bowel disease | Il2tm1Hor/Il2tm1Hor | involves: 129P2/OlaHsd * C57BL/6 | J:15223 | View | ||||
| inflammatory bowel disease | Il2ratm1Dw/Il2ratm1Dw | involves: 129S4/SvJae * C57BL/6 | J:64279 | View | ||||
| inflammatory bowel disease | Muc2eey/Muc2eey | C57BL/6-Muc2eey | J:194148 | View | ||||
| inflammatory bowel disease | Muc2tm1Avel/Muc2tm1Avel | involves: 129P2/OlaHsd * C57BL/6 | J:216831 | View | ||||
| inflammatory bowel disease | Muc2wnn/Muc2wnn | C57BL/6-Muc2wnn | J:194148 | View | ||||
| inflammatory bowel disease | Nfil3tm1Pbro/Nfil3tm1Pbro | B6.129S6-Nfil3tm1Pbro | J:209365 | View | ||||
| inflammatory bowel disease | Runx3tm1Yg/Runx3tm1Yg | either: (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) | J:93240 | View | ||||
| inflammatory bowel disease | St6galnac1em1Len/St6galnac1em1Len | Not Specified | J:324883 | View | ||||
| inflammatory bowel disease |
Stat3tm1Dlv/Stat3tm1Dlv Tg(Csf1r-icre)1Jwp/0 |
involves: 129P2/OlaHsd * C57BL/6 * FVB | J:156593 | View | ||||
| inflammatory bowel disease |
Stat3tm1Flv/Stat3tm1Flv Tg(Tek-cre)1Xyfu/0 |
involves: C57BL/6 | J:86655 | View | ||||
| inflammatory bowel disease |
Stat3tm1Flv/Stat3tm1Flv Tg(Tek-cre)12Flv/0 |
involves: 129 * C3H * C57BL/6 | J:81973 | View | ||||
| inflammatory bowel disease | Tg(Igh-V-CD40lg)#Tsub/0 | involves: C57BL/6 | J:89855 | View | ||||
| inflammatory bowel disease | Tnftm1Gkl/Tnftm2Gkl | involves: 129S/SvEv * C57BL/6 | J:54056 | View | ||||
| inflammatory bowel disease |
Tnftm2.1Gkl/Tnftm2.1Gkl Tg(Fabp1-cre)1Jig/0 |
involves: 129S/SvEv * FVB/N | J:204557 | View | ||||
| inflammatory bowel disease | Tnftm2Gkl/Tnf+ | involves: 129S/SvEv * C57BL/6 | J:54056, J:136667, J:204922 | View | ||||
| inflammatory bowel disease | Tnftm2Gkl/Tnftm2Gkl | involves: 129S/SvEv * C57BL/6 | J:54056 | View | ||||
| inflammatory bowel disease |
Xbp1tm2Glm/Xbp1tm2Glm Tg(Vil1-cre)997Gum/0 |
involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL | J:188627 | View | ||||
| inflammatory bowel disease 1 | Nod2tm1Mka/Nod2tm1Mka | involves: C57BL/6 | J:96128 | View | ||||
| inflammatory bowel disease 12 | Gnai2tm1Lbi/Gnai2tm1Lbi | involves: 129S7/SvEvBrd | J:24434, J:30507 | View | ||||
| inflammatory bowel disease 12 | Gnai2tm1Lbi/Gnai2tm1Lbi | involves: 129S7/SvEvBrd * C57BL/6 | J:91100 | View | ||||
| inflammatory bowel disease 12 | Gnai2tm1Lbi/Gnai2tm1Lbi | involves: 129S7/SvEvBrd * C57BL/6J | J:24434 | View | ||||
| inflammatory bowel disease 16 | Tg(Csf1r-Tnfsf15,-EGFP)#Targ/0 | involves: C57BL/6 | J:169462 | View | ||||
| inflammatory bowel disease 16 | Tg(Lck-Tnfsf15,-EGFP)#Targ/0 | involves: C57BL/6 | J:169462 | View | ||||
| intestinal atresia | Fgf10tm1Ska/Fgf10tm1Ska | involves: C57BL/6 * CBA | J:92361 | View | ||||
| intestinal atresia | Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn | involves: 129P2/OlaHsd * C57BL/6 | J:92361 | View | ||||
| intestinal pseudo-obstruction | Nup35m1Apb/Nup35m1Apb | involves: C57BL/6N | J:235141 | View | ||||
| intestinal pseudo-obstruction |
Ptentm1Hwu/Ptentm1Hwu Tg(Tyr-cre)1Lru/0 |
B6.Cg-Ptentm1Hwu Tg(Tyr-cre)1Lru | J:155110 | View | ||||
| intestinal pseudo-obstruction | Spry2tm1Ayos/Spry2tm1Ayos | B6.Cg-Spry2tm1Ayos | J:99827 | View | ||||
| intestinal pseudo-obstruction | Tlx2tm1Htno/Tlx2tm1Htno | involves: 129S1/Sv * 129X1/SvJ | J:42356 | View | ||||
| intestinal pseudo-obstruction | Tlx2tm1Sjk/Tlx2tm1Sjk | involves: 129/Sv * C57BL/6 | J:40722 | View | ||||
| irritable bowel syndrome | Mlxipltm1Kuy/Mlxipltm1Kuy | B6.129S6-Mlxipltm1Kuy/J | J:273754 | View | ||||
| Transgenes and Other Mutations | colorectal cancer |
Tg(tetO-MYC)36aBop/0 Tg(Cebpb-tTA)5Bjd/0 |
involves: FVB/N * NMRI | J:190067 | View | |||
| Hirschsprung's disease | Tg(Sox3-GFP,Tyr)HolNpln/Tg(Sox3-GFP,Tyr)HolNpln | involves: FVB/N | J:229828 | View | ||||
| Hirschsprung's disease | Tg(SRY-YFP,Tyr)TashTNpln/Tg(SRY-YFP,Tyr)TashTNpln | involves: FVB/N | J:224231 | View | ||||
| inflammatory bowel disease | Tcratm1Mom/Tcratm1Mom | B6.129S2-Tcratm1Mom | J:135597 | View | ||||
| inflammatory bowel disease | Tcratm1Mom/Tcratm1Mom | involves: 129S2/SvPas * C57BL/6 | J:15221 | View | ||||
| Additional Complex Models | anal canal carcinoma |
Ptentm1Hwu/Ptentm1Hwu Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Tg(KRT14-cre/ERT)20Efu/0 |
involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N | J:209026 | View | |||
| colorectal cancer |
Il10tm1Cgn/Il10tm1Cgn Tg(MUC1)79.24Gend/0 |
B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend | J:149347 | View | ||||
| colorectal cancer |
Rab25tm1Jrgo/Rab25tm1Jrgo Smad3tm1Par/Smad3+ |
129-Rab25tm1Jrgo Smad3tm1Par | J:158733 | View | ||||
| duodenum cancer |
B3gnt6tm1Lx/B3gnt6tm1Lx C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc Tg(Vil1-cre)997Gum/0 |
involves: 129S1/Sv * C57BL/6J * SJL | J:239765 | View | ||||
| duodenum cancer |
B3gnt6tm1Lx/B3gnt6tm1Lx C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc Tg(Vil1-cre/ERT2)23Syr/0 |
involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 | J:23965 | View | ||||
| inflammatory bowel disease |
Gpx1tm1Ysh/Gpx1+ Gpx2tm2Coh/Gpx2tm2Coh |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:71506 | View | ||||
| inflammatory bowel disease |
Gpx1tm1Ysh/Gpx1tm1Ysh Gpx2tm2Coh/Gpx2tm2Coh |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:71506 | View | ||||
| inflammatory bowel disease |
Il10rbtm1Agt/Il10rbtm1Agt Tg(Cd4-TGFBR2)16Flv/? |
involves: 129S2/SvPas * C3H * C57BL/6 | J:134156 | View | ||||
| ulcerative colitis |
Rag2tm1Fwa/Rag2tm1Fwa Tbx21tm1Glm/Tbx21tm1Glm |
involves: 129S/SvEv * 129S6/SvEvTac | J:141481 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | inflammatory bowel disease 12 | Gnai2tm1Lbi/Gnai2tm1Lbi | 129-Gnai2tm1Lbi | J:91100 | View | |||