Fgfr2^tm1.1Dsn
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm1.1Dsn
• Name: fibroblast growth factor receptor 2; targeted mutation 1.1, Clive Dickson
• MGI ID: MGI:2153811
• Synonyms: Fgfr2b-, Fgfr2(IIIb)-, FgfR2-IIIb^-Cre
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm1.1Dsn page

Palatal abnormalities in Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn and Fgf10^tm1Wss/Fgf10^tm1Wss mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59285
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Fgfr2^tm1Dsn in which exon IIIb was excised in the germline as follows: Cre recombinase was transiently expressed in fertilized C57BL/6 x Fgfr2^{tm1Dsn/tm1Dsn} eggs by injection of an expression vector. Resulting progeny were screened for animals with a deletion of exon IIIb. Abnormally spliced transcripts are produced from this allele that splice exon IIIa to the transmembrane domain and the resulting frameshift is predicted to result in a termination codon in the transmembrane domain of the encoded protein. However, a normal IIIa to IIIc and TM transcript is made and is prediced to result in a normal isoform of the protein. (J:59285)

Disease models

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	46 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 91 strains or lines available

References

• Original: J:59285 De Moerlooze L, et al., An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development. 2000 Feb;127(3):483-92
• All: 24 reference(s)