Atg16l1Gt(XR0164)Wtsi
Gene trapped Allele Detail
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Symbol: |
Atg16l1Gt(XR0164)Wtsi |
Name: |
autophagy related 16 like 1; gene trap XR0164, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:3818575 |
Synonyms: |
ATG16L1Hm2 |
Gene: |
Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
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Alliance: |
Atg16l1Gt(XR0164)Wtsi page
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Mutant Cell Line: |
XR0164 |
Germline Transmission: |
Earliest citation of germline transmission:
J:141419
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Parent Cell Line: |
E14TG2a.4 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Project Collection: |
Sanger Inst. Gene Trap Res.
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Allele Type: |
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Gene trapped (Hypomorph) |
Mutation: |
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Insertion of gene trap vector
Vector: pGT0lxf
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Mutation details: A gene-trap vector containing a splice acceptor followed by a beta-geo cassette disrupted the gene locus by inserting within the intronic region after exon 10. Protein expression of both the alpha and beta isoforms of the gene product were 23-37% of wild-type as determined by immunoblots of ileal lystates from homozygotes. This is a hypomorphic allele.
(J:141419)
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Sequence Tags: |
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Sequence tag details (1 tag)
Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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Genome Context: |
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Genome Browser view of this mutation
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Atg16l1 Mutation: |
44 strains or lines available
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Original: |
J:141419 Cadwell K, et al., A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008 Nov 13;456(7219):259-63 |
All: |
8 reference(s) |
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